PROSITE documentation PDOC00959
Uncharacterized protein family UPF0003 signature


The following uncharacterized proteins have been shown [1] to share regions of similarities:

  • Escherichia coli protein aefA.
  • Escherichia coli hypothetical protein yggB.
  • Escherichia coli hypothetical protein yjeP and HI0195.1, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein ynaI.
  • Bacillus subtilis hypothetical protein yhdY.
  • Helicobacter pylori hypothetical protein HP0415.
  • Synechocystis strain PCC 6803 hypothetical protein slr0639.
  • Archaeoglobus fulgidus hypothetical protein AF1546.
  • Methanococcus jannaschii hypothetical protein MJ0170.
  • Methanococcus jannaschii hypothetical protein MJ1143.

The size of these proteins range from 30 to 120 Kd. They all contain a number of transmembrane regions. As a signature pattern, we selected the best conserved region which is located in and just after the last potential transmembrane region.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

UPF0003, PS01246; Uncharacterized protein family UPF0003 signature  (PATTERN)


1AuthorsBairoch A.
SourceUnpublished observations (1997).

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