We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00964Endogenous opioids neuropeptides precursors signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00964
Description
Vertebrate endogenous opioids neuropeptides are released by post-translational proteolytic processing of precursor proteins. These precursor proteins consist of a signal sequence followed by a conserved region of about 50 residues, a variable length region and the sequence of the various neuropeptides. Three types of precursors are currently known:
- Preproenkephalin A (gene PENK) which is processed to produce the peptides Met-enkephalin (6 copies) and Leu-enkephalin,
- Preproenkephalin B (gene PDYN) which is processed to produce the peptides neoendorphin, dynorphin, leumorphin, rimorphin and leu-enkephalin.
- Prepronocipeptin (gene PNOC) which is processed to produce the peptides nociceptin (orphanin FQ) as well as two other potential neuropeptides.
The conserved region in the N-terminal of these precursors contains six cysteines that are probably involved in disulfide bonds. This region could be important for the processing of the neuropeptides [1].
Last update:May 2004 / Text revised.
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Technical section
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Reference
| 1 | Authors | Mollereau C. Simons M.-J. Soularue P. Liners F. Vassart G. Meunier J.-C. Parmentier M. |
| Title | Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996). | |
| PubMed ID | 8710928 |
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