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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS01252


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PURL: https://purl.expasy.org/prosite/signature/PS01252

Direct ScanProsite submission
General information about the entry

Entry name [info] OPIOIDS_PRECURSOR
Accession [info] PS01252
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-JUL-1999 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00964

Name and characterization of the entry

Description [info] Endogenous opioids neuropeptides precursors signature.
Pattern [info] 
C-x(3)-C-x(2)-C-x(2)-[KRH]-x(6,7)-[LIF]-[DNS]-x(3)-C-x-[LIVM]-[EQ]-C-
[EQ]-x(8)-W-x(2)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 17 in 17 different sequences
Number of true positive hits 17 in 17 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 94.44 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide(?) at position 1
Site [info] disulfide(?) at position 3
Site [info] disulfide(?) at position 5
Site [info] disulfide(?) at position 12
Site [info] disulfide(?) at position 16
Site [info] disulfide(?) at position 21
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 17 sequences 

PDYN_BOVIN  (Q95104), PDYN_CAVPO  (Q60478), PDYN_HUMAN  (P01213), 

PDYN_MOUSE  (O35417), PDYN_PIG(P01214), PDYN_RAT(P06300), 
PENKA_XENLA (P01212), PENK_BOVIN  (P01211), PENK_CAVPO  (P47969), 
PENK_HUMAN  (P01210), PENK_MESAU  (P50175), PENK_MOUSE  (P22005), 
PENK_RAT(P04094), PNOC_BOVIN  (O62647), PNOC_HUMAN  (Q13519), 
PNOC_MOUSE  (Q64387), PNOC_RAT(Q62923)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

PENKV_MEIAT (P0DP56)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			3 sequences
			


			
PENKB_XENLA (P07194), PENK_FELCA  (Q28409), PNOC_PIG(P55791)