We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00967Cullin family signature and profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00967
Description
The following proteins are collectively termed cullins [1]:
- Caenorhabditis elegans cul-1 (or lin-19), a protein required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
- Caenorhabditis elegans cul-2, cul-3, cul-4 (F45E12.3), cul-5 (ZK856.1) and cul-6 (K08E7.7).
- Mammalian CUL1, CUL2, CUL3, CUL4A and CUL4B.
- Mammalian vasopressin-activated calcium-mobilizing receptor (VACM-1), a kidney-specific protein thought to form a cell surface receptor [2] but which does not have any structural hallmarks of a receptor.
- Drosophila lin19.
- Yeast CDC53 [3], which acts in concert with CDC4 and UBC3 (CDC34) to control the G1-to-S phase transition.
- Yeast hypothetical protein YGR003w.
- Fission yeast hypothetical protein SpAC24H6.03.
The cullins are hydrophilic proteins of 740 to 815 amino acids. The C-terminal extremity is the most conserved part of these proteins. We have developed a signature pattern from that region.
Note:This documentation entry is linked to both a signature pattern and a profile. As the profile is much more sensitive than the pattern, you should use it if you have access to the necessary software tools to do so.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE methods (with tools and information) covered by this documentation:
References
| 1 | Authors | Kipreos E.T. Lander L.E. Wing J.P. He W.W. Hedgecock E.M. |
| Title | cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. | |
| Source | Cell 85:829-839(1996). | |
| PubMed ID | 8681378 |
| 2 | Authors | Burnatowska-Hledin M.A. Spielman W.S. Smith W.L. Shi P. Meyer J.M. Dewitt D.L. |
| Source | Am. J. Physiol. 268:f1198-F1210(1995). |
| 3 | Authors | Mathias N. Johnson S.L. Winey M. Adams A.E. Goetsch L. Pringle J.R. Byers B. Goebl M.G. |
| Title | Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. | |
| Source | Mol. Cell. Biol. 16:6634-6643(1996). | |
| PubMed ID | 8943317 |
Copyright
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