PROSITE documentation PDOC00967
Cullin family signature and profile


The following proteins are collectively termed cullins [1]:

  • Caenorhabditis elegans cul-1 (or lin-19), a protein required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
  • Caenorhabditis elegans cul-2, cul-3, cul-4 (F45E12.3), cul-5 (ZK856.1) and cul-6 (K08E7.7).
  • Mammalian CUL1, CUL2, CUL3, CUL4A and CUL4B.
  • Mammalian vasopressin-activated calcium-mobilizing receptor (VACM-1), a kidney-specific protein thought to form a cell surface receptor [2] but which does not have any structural hallmarks of a receptor.
  • Drosophila lin19.
  • Yeast CDC53 [3], which acts in concert with CDC4 and UBC3 (CDC34) to control the G1-to-S phase transition.
  • Yeast hypothetical protein YGR003w.
  • Fission yeast hypothetical protein SpAC24H6.03.

The cullins are hydrophilic proteins of 740 to 815 amino acids. The C-terminal extremity is the most conserved part of these proteins. We have developed a signature pattern from that region.


This documentation entry is linked to both a signature pattern and a profile. As the profile is much more sensitive than the pattern, you should use it if you have access to the necessary software tools to do so.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

CULLIN_2, PS50069; Cullin family profile  (MATRIX)

CULLIN_1, PS01256; Cullin family signature  (PATTERN)


1AuthorsKipreos E.T. Lander L.E. Wing J.P. He W.W. Hedgecock E.M.
Titlecul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
SourceCell 85:829-839(1996).
PubMed ID8681378

2AuthorsBurnatowska-Hledin M.A. Spielman W.S. Smith W.L. Shi P. Meyer J.M. Dewitt D.L.
SourceAm. J. Physiol. 268:f1198-F1210(1995).

3AuthorsMathias N. Johnson S.L. Winey M. Adams A.E. Goetsch L. Pringle J.R. Byers B. Goebl M.G.
TitleCdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.
SourceMol. Cell. Biol. 16:6634-6643(1996).
PubMed ID8943317

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