PROSITE documentation PDOC00970
Eukaryotic initiation factor 1A signature


Eukaryotic translation initiation factor 1A (eIF-1A) [1] (formerly known as eiF-4C) is a protein that seems to be required for maximal rate of protein biosynthesis. It enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA to 40S ribosomal subunits.

eIF-1A is a hydrophilic protein of about 15 to 17 Kd. Archaebacteria also seem to possess a eIF-1A homolog.

As a signature pattern, we selected a conserved region in the central section of these proteins.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

IF1A, PS01262; Eukaryotic initiation factor 1A signature  (PATTERN)


1AuthorsWei C.-L. Kainuma M. Hershey J.W.B.
TitleCharacterization of yeast translation initiation factor 1A and cloning of its essential gene.
SourceJ. Biol. Chem. 270:22788-22794(1995).
PubMed ID7559407

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