We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00970Eukaryotic initiation factor 1A signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00970
Description
Eukaryotic translation initiation factor 1A (eIF-1A) [1] (formerly known as eiF-4C) is a protein that seems to be required for maximal rate of protein biosynthesis. It enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA to 40S ribosomal subunits.
eIF-1A is a hydrophilic protein of about 15 to 17 Kd. Archaebacteria also seem to possess a eIF-1A homolog.
As a signature pattern, we selected a conserved region in the central section of these proteins.
Last update:December 2004 / Pattern and text revised.
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Technical section
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Reference
| 1 | Authors | Wei C.-L. Kainuma M. Hershey J.W.B. |
| Title | Characterization of yeast translation initiation factor 1A and cloning of its essential gene. | |
| Source | J. Biol. Chem. 270:22788-22794(1995). | |
| PubMed ID | 7559407 |
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