PROSITE documentation PDOC00982
Peptidase family U32 signature


Porphyromonas gingivalis collagenase (gene prtC) [1] is an enzyme that degrades type I collagen and that seems to require a metal cofactor. PrtC is evolutionary related to a number of uncharacterized proteins:

  • Escherichia coli hypothetical protein ydcP.
  • Escherichia coli hypothetical protein yegQ, and HI0419, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein yhbU.
  • Helicobacter pylori hypothetical protein HP0169.
  • Methanococcus jannaschii hypothetical protein MJ0090.

A well conserved region containing two cysteines can be used as a signature pattern for these proteins.


These proteins belong to family U32 in the classification of peptidases [E1].

Last update:

November 1997 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PEPTIDASE_U32, PS01276; Peptidase family U32 signature  (PATTERN)


1AuthorsKato T. Takahashi N. Kuramitsu H.K.
TitleSequence analysis and characterization of the Porphyromonas gingivalis prtC gene, which expresses a novel collagenase activity.
SourceJ. Bacteriol. 174:3889-3895(1992).
PubMed ID1317840


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