PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE documentation PDOC00982
Peptidase family U32 signature


View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00982

Description

Porphyromonas gingivalis collagenase (gene prtC) [1] is an enzyme that degrades type I collagen and that seems to require a metal cofactor. PrtC is evolutionary related to a number of uncharacterized proteins:

  • Escherichia coli hypothetical protein ydcP.
  • Escherichia coli hypothetical protein yegQ, and HI0419, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein yhbU.
  • Helicobacter pylori hypothetical protein HP0169.
  • Methanococcus jannaschii hypothetical protein MJ0090.

A well conserved region containing two cysteines can be used as a signature pattern for these proteins.

Note:

These proteins belong to family U32 in the classification of peptidases [E1].

Last update:

November 1997 / First entry.

-------------------------------------------------------------------------------


Technical section

PROSITE method (with tools and information) covered by this documentation:

PEPTIDASE_U32, PS01276; Peptidase family U32 signature  (PATTERN)


References

1AuthorsKato T. Takahashi N. Kuramitsu H.K.
TitleSequence analysis and characterization of the Porphyromonas gingivalis prtC gene, which expresses a novel collagenase activity.
SourceJ. Bacteriol. 174:3889-3895(1992).
PubMed ID1317840

E1Titlehttps://www.uniprot.org/docs/peptidas



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.