|PROSITE documentation PDOC00985|
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC 22.214.171.124) (PCMT)  (which is also known as L-isoaspartyl protein carboxyl methyltransferase) is an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to the free carboxyl groups of D-aspartyl or L-isoaspartyl residues in a variety of peptides and proteins. The enzyme does not act on normal L-aspartyl residues L-isoaspartyl and D-aspartyl are the products of the spontaneous deamidation and/or isomerization of normal L-aspartyl and L-asparaginyl residues in proteins. PCMT plays a role in the repair and/or degradation of these damaged proteins; the enzymatic methyl esterification of the abnormal residues can lead to their conversion to normal L-aspartyl residues.
PCMT is a well-conserved and widely distributed cytosolic protein of about 24 Kd. As a signature pattern, we selected a conserved region in the central part of this enzyme.Last update:
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Kagan R.M. McFadden H.J. McFadden P.N. O'Connor C. Clarke S.|
|Title||Molecular phylogenetics of a protein repair methyltransferase.|
|Source||Comp. Biochem. Physiol. 117b:379-385(1997).|