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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS01279


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PURL: https://purl.expasy.org/prosite/signature/PS01279

Direct ScanProsite submission
General information about the entry

Entry name [info] PCMT
Accession [info] PS01279
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00985

Name and characterization of the entry

Description [info] Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature.
Pattern [info]
[GSAED]-[DN]-G-x(2)-G-[FYWLV]-x(3)-[GSA]-[PTL]-[FY]-[DNSHE]-x-I.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 296 in 296 different sequences
Number of true positive hits 295 in 295 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 45
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.66 %
Recall (true positives / (true positives + false negatives)) 86.76 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
295 sequences

PIMT1_ARATH (Q42539), PIMT1_ARCFU (O30199), PIMT1_CUPNH (Q0KB67), 
PIMT1_GEOUR (A5GEF7), PIMT1_MARN8 (A1TZ54), PIMT1_METAC (Q8TT93), 
PIMT1_NITMU (Q2YCR1), PIMT1_RHOP2 (Q2J302), PIMT1_SHESH (A8FST4), 
PIMT1_SYNFM (A0LL58), PIMT2_ARATH (Q64J17), PIMT2_ARCFU (O27962), 
PIMT2_CUPNH (Q0K951), PIMT2_GEOUR (A5G4S7), PIMT2_MARN8 (A1U4P7), 
PIMT2_METAC (Q8TT94), PIMT2_NITMU (Q2YBR7), PIMT2_NITOC (Q3JAW6), 
PIMT2_PELPD (A1ASW6), PIMT2_POLSJ (Q123X2), PIMT2_SHESH (A8FX24), 
PIMT2_SYNFM (A0LM89), PIMT_AERHH  (A0KGH9), PIMT_AERPE  (Q9YDA1), 
PIMT_AERS4  (A4SRB5), PIMT_ALCBS  (Q0VQD1), PIMT_ALIF1  (Q5E332), 
PIMT_ALIFM  (B5FAF3), PIMT_ALISL  (B6EKL2), PIMT_ALTMD  (B4RZG8), 
PIMT_ANAD2  (B8J9E3), PIMT_ANADE  (Q2IIL9), PIMT_AROAE  (Q5P833), 
PIMT_AZOC5  (A8I4G3), PIMT_AZOSB  (A1K4F0), PIMT_BORA1  (Q2L008), 
PIMT_BORBR  (Q7WI37), PIMT_BORPA  (Q7W671), PIMT_BORPD  (A9IP04), 
PIMT_BOVIN  (P15246), PIMT_BRUA4  (A6X6Y1), PIMT_BURA4  (B1YRE4), 
PIMT_BURCH  (A0K7U6), PIMT_BURCM  (Q0BEV7), PIMT_BURL3  (Q39FP9), 
PIMT_BURM7  (A3MK86), PIMT_BURM9  (A2S291), PIMT_BURMA  (Q62JV3), 
PIMT_BURMS  (A1V4L2), PIMT_BURO0  (B1JTA2), PIMT_BURO1  (Q1BGY4), 
PIMT_BURP0  (A3NVY1), PIMT_BURP1  (Q3JRP1), PIMT_BURP6  (A3NA64), 
PIMT_BURPS  (Q63UU3), PIMT_BURTA  (Q2SWF4), PIMT_BURVG  (A4JEQ0), 
PIMT_CAEEL  (Q27873), PIMT_CAUSK  (B0T1Q1), PIMT_CAUVC  (Q9A6T6), 
PIMT_CAUVN  (B8GX51), PIMT_CERS1  (A3PIZ8), PIMT_CERS4  (Q3J3D1), 
PIMT_CERS5  (A4WU05), PIMT_CERSK  (B9KQZ1), PIMT_CHICK  (Q5F3N1), 
PIMT_CHLL2  (B3EEX3), PIMT_CHLP8  (B3QQM1), PIMT_CHLPB  (B3ELJ9), 
PIMT_CHLPD  (A1BDC1), PIMT_CHLPM  (A4SGH4), PIMT_CHLTE  (Q8KFW8), 
PIMT_CHRSD  (Q1QU77), PIMT_CHRVO  (Q7NRV0), PIMT_CITK8  (A8ANV7), 
PIMT_COLP3  (Q487E5), PIMT_CROS8  (A7MJ61), PIMT_CUPPJ  (Q46ZH2), 
PIMT_CYTH3  (Q11TS0), PIMT_DANRE  (Q92047), PIMT_DECAR  (Q47D25), 
PIMT_DESOH  (A8ZXR8), PIMT_DESPS  (Q6ARM1), PIMT_DICT6  (B5YF00), 
PIMT_DICTD  (B8E0T1), PIMT_DINSH  (A8LQK6), PIMT_DROME  (Q27869), 
PIMT_ECO24  (A7ZQI7), PIMT_ECO27  (B7UHG2), PIMT_ECO45  (B7MKL7), 
PIMT_ECO55  (B7LEG1), PIMT_ECO57  (P0A7A6), PIMT_ECO5E  (B5Z3A5), 
PIMT_ECO7I  (B7NT87), PIMT_ECO81  (B7MZ44), PIMT_ECO8A  (B7LXF5), 
PIMT_ECOBW  (C4ZZP7), PIMT_ECODH  (B1XCR9), PIMT_ECOHS  (A8A3M2), 
PIMT_ECOK1  (A1AET7), PIMT_ECOL6  (Q8FEJ8), PIMT_ECOLC  (B1IUT6), 
PIMT_ECOLI  (P0A7A5), PIMT_ECOLU  (B7N6X3), PIMT_ECOSE  (B6I6D3), 
PIMT_ECOSM  (B1LQ63), PIMT_ECOUT  (Q1R7U8), PIMT_ECTM1  (A4XWR1), 
PIMT_ENT38  (A4WDU8), PIMT_ERWT9  (B2VG25), PIMT_ESCF3  (B7LWJ2), 
PIMT_FERNB  (A7HL14), PIMT_FLAJ1  (A5FEA5), PIMT_FLAPJ  (A6H0V1), 
PIMT_GEOMG  (Q39VS0), PIMT_GEOSL  (Q74CZ5), PIMT_GLOVI  (Q7NJY2), 
PIMT_HAHCH  (Q2SKW3), PIMT_HALHL  (A1WWY5), PIMT_HELP2  (B6JMT1), 
PIMT_HELPG  (B5Z887), PIMT_HELPJ  (Q9ZKC2), PIMT_HELPY  (P56133), 
PIMT_HERA2  (A9AUP1), PIMT_HERAR  (A4G4J3), PIMT_HUMAN  (P22061), 
PIMT_HYPBU  (A2BKH8), PIMT_IDILO  (Q5QUB2), PIMT_IGNH4  (A8AAV7), 
PIMT_JANMA  (A6SZX9), PIMT_KLEP3  (B5XV38), PIMT_KLEP7  (A6TD35), 
PIMT_KORVE  (Q1INS6), PIMT_LAWIP  (Q1MRE5), PIMT_MACFA  (Q4R5H0), 
PIMT_MARMM  (Q0ANE2), PIMT_MARSD  (C6BTT9), PIMT_METB6  (A7I4W9), 
PIMT_METBU  (Q12UV0), PIMT_METEP  (A9VY77), PIMT_METFK  (Q1H095), 
PIMT_METJA  (Q57636), PIMT_METKA  (Q8TYL4), PIMT_METM5  (A4G087), 
PIMT_METM6  (A9A8I9), PIMT_METM7  (A6VI91), PIMT_METMA  (Q8PW90), 
PIMT_METMJ  (A3CXP8), PIMT_METMP  (Q6M116), PIMT_METPB  (B1ZJW1), 
PIMT_METTH  (O26915), PIMT_METTP  (A0B9U1), PIMT_MOUSE  (P23506), 
PIMT_MYXXD  (Q1D6W9), PIMT_NITEC  (Q0ADP2), PIMT_NITEU  (Q82VW0), 
PIMT_NITV2  (Q72AZ1), PIMT_NITV4  (A1VD15), PIMT_NITV9  (B8DJP7), 
PIMT_OLEA2  (Q30ZM2), PIMT_OPITP  (B1ZPF0), PIMT_PARDP  (A1B5M0), 
PIMT_PARL1  (A7HXK6), PIMT_PARM1  (Q2W4A2), PIMT_PARP8  (B2JG67), 
PIMT_PARUW  (Q6MCW9), PIMT_PECAS  (Q6D1B6), PIMT_PECCP  (C6DDF9), 
PIMT_PELPB  (B4SFU3), PIMT_PELTS  (A5CYQ6), PIMT_PHOLL  (Q7N8K3), 
PIMT_PHOPR  (Q6LMT7), PIMT_PICP2  (B1XQE1), PIMT_PIG(P80895), 
PIMT_PONAB  (Q5RA89), PIMT_PROMH  (B4F223), PIMT_PSE14  (Q48F88), 
PIMT_PSEA6  (Q15P27), PIMT_PSEA8  (B7V8C3), PIMT_PSEAB  (Q02R96), 
PIMT_PSEAE  (P45683), PIMT_PSEE4  (Q1I655), PIMT_PSEF5  (Q4KHE7), 
PIMT_PSEFS  (C3K706), PIMT_PSEP1  (A5W820), PIMT_PSEP7  (A6V1G4), 
PIMT_PSEPF  (Q3KH83), PIMT_PSEPG  (B0KSC8), PIMT_PSEPK  (Q88MF0), 
PIMT_PSEPW  (B1JB29), PIMT_PSESM  (Q886L4), PIMT_PSET1  (Q3IDD2), 
PIMT_PSEU2  (Q4ZWP9), PIMT_PYRAB  (Q9UXX0), PIMT_PYRAE  (Q8ZYN0), 
PIMT_PYRAR  (A4WNC5), PIMT_PYRFU  (Q8TZR3), PIMT_PYRHO  (O59534), 
PIMT_PYRIL  (A1RSC6), PIMT_PYRNV  (B1YC47), PIMT_RALN1  (Q8Y039), 
PIMT_RAT(P22062), PIMT_RHIME  (O08249), PIMT_RHOCS  (B6ISM3), 
PIMT_RHOPA  (Q6NCU3), PIMT_RHORT  (Q2RTH7), PIMT_ROSCS  (A7NI01), 
PIMT_ROSDO  (Q163U2), PIMT_ROSS1  (A5UZW2), PIMT_RUEPO  (Q5LQ09), 
PIMT_SACD2  (Q21LB7), PIMT_SALA4  (B5F407), PIMT_SALAR  (A9MF32), 
PIMT_SALCH  (Q57KJ8), PIMT_SALDC  (B5FTS1), PIMT_SALEP  (B5QW14), 
PIMT_SALG2  (B5RDP9), PIMT_SALHS  (B4TFW3), PIMT_SALNS  (B4T453), 
PIMT_SALPA  (Q5PEE9), PIMT_SALPB  (A9N1H6), PIMT_SALPC  (C0PXA3), 
PIMT_SALPK  (B5BEY0), PIMT_SALRD  (Q2S176), PIMT_SALSV  (B4TTV7), 
PIMT_SALTI  (Q8Z474), PIMT_SALTY  (Q8ZMF9), PIMT_SERP5  (A8G9Z6), 
PIMT_SHEAM  (A1S4E3), PIMT_SHEB2  (B8E8T7), PIMT_SHEB5  (A3D789), 
PIMT_SHEB8  (A6WR22), PIMT_SHEB9  (A9KYG4), PIMT_SHEDO  (Q12PY8), 
PIMT_SHEFN  (Q086A4), PIMT_SHEHH  (B0TK10), PIMT_SHELP  (A3QC83), 
PIMT_SHEON  (Q8EBR6), PIMT_SHEPA  (A8H1T1), PIMT_SHEPC  (A4Y937), 
PIMT_SHEPW  (B8CJQ2), PIMT_SHESA  (A0KU88), PIMT_SHESM  (Q0HL66), 
PIMT_SHESR  (Q0HXG4), PIMT_SHESW  (A1RHF9), PIMT_SHEWM  (B1KPT0), 
PIMT_SHIB3  (B2TZI8), PIMT_SHIBS  (Q31XA5), PIMT_SHIDS  (Q32CI7), 
PIMT_SHIF8  (Q0T1H4), PIMT_SHIFL  (Q83JY3), PIMT_SHISS  (Q3YYB9), 
PIMT_SODGM  (Q2NVM1), PIMT_STAMF  (A3DMG3), PIMT_STRM5  (B4SR93), 
PIMT_STRMK  (B2FK95), PIMT_STUS1  (A4VJV3), PIMT_SYNAS  (Q2LUT4), 
PIMT_SYNJB  (Q2JJN4), PIMT_THEM4  (A6LNM3), PIMT_THEMA  (Q56308), 
PIMT_THEON  (B6YX51), PIMT_THESM  (C6A3F2), PIMT_TRIL1  (B3E6I4), 
PIMT_VIBA3  (B7VK62), PIMT_VIBC1  (A7MTT6), PIMT_VIBC3  (A5F9C1), 
PIMT_VIBCH  (Q9KUI8), PIMT_VIBCM  (C3LS22), PIMT_VIBPA  (Q87LQ6), 
PIMT_VIBVU  (Q8DC56), PIMT_VIBVY  (Q7MHQ8), PIMT_WHEAT  (Q43209), 
PIMT_XANAC  (Q8PLR3), PIMT_XANC8  (Q4UTP9), PIMT_XANCB  (B0RTZ8), 
PIMT_XANCP  (Q8P9Y6), PIMT_XANE5  (Q3BUS3), PIMT_XANOM  (Q2P1L5), 
PIMT_XANOP  (B2SUB3), PIMT_XANOR  (Q5GYL2), PIMT_XYLF2  (B2I8X8), 
PIMT_XYLFA  (Q9PF21), PIMT_XYLFM  (B0U4U6), PIMT_XYLFT  (Q87AK5), 
PIMT_YERE8  (A1JJT8), PIMT_YERP3  (A7FLX4), PIMT_YERPA  (Q1C474), 
PIMT_YERPB  (B2K581), PIMT_YERPE  (Q8ZBQ0), PIMT_YERPG  (A9R115), 
PIMT_YERPN  (Q1CLR2), PIMT_YERPP  (A4TQ01), PIMT_YERPS  (Q66EB9), 
PIMT_YERPY  (B1JJF4)
» more

UniProtKB/Swiss-Prot
False negative sequences
45 sequences

PCMD1_BOVIN (A2VDP2), PCMD1_CHICK (Q5ZMR3), PCMD1_HUMAN (Q96MG8), 
PCMD1_MOUSE (P59913), PCMD1_PONAB (Q5R7E5), PCMD2_HUMAN (Q9NV79), 
PCMD2_MOUSE (Q8BHD8), PCMD2_PONAB (Q5R7K4), PIMT1_ANADF (A7HC32), 
PIMT1_NITOC (Q3JCZ3), PIMT1_PELPD (A1ASL8), PIMT1_POLSJ (Q12A85), 
PIMT2_ANADF (A7HHV3), PIMT2_RHOP2 (Q2IWH1), PIMT3_GEOUR (A5G6S0), 
PIMT_AFIC5  (B6JFP0), PIMT_ALKEH  (Q0A7L5), PIMT_BRASB  (A5EJV5), 
PIMT_BRASO  (A4YV66), PIMT_CELJU  (B3PJA8), PIMT_CHLL3  (Q3B1L6), 
PIMT_CHRFK  (A0LZ51), PIMT_DESDA  (B8J017), PIMT_DICDI  (Q9GPS6), 
PIMT_JANSC  (Q28TH8), PIMT_KORCO  (B1L6T9), PIMT_LEPCP  (B1Y0T0), 
PIMT_MAGMM  (A0L4K5), PIMT_META3  (A6UWM1), PIMT_METAR  (Q0W2W0), 
PIMT_METHJ  (Q2FRW3), PIMT_METPP  (A2SF76), PIMT_METVS  (A6UR90), 
PIMT_NATTJ  (B2A578), PIMT_NITWN  (Q3SRQ7), PIMT_PETMO  (A9BH07), 
PIMT_PYRCJ  (A3MY16), PIMT_RHOP5  (Q07N42), PIMT_RHOPB  (Q214W4), 
PIMT_RHOPS  (Q136H9), PIMT_RUEST  (Q1GFP1), PIMT_SCHPO  (Q9URZ1), 
PIMT_SYNC1  (Q3A4N4), PIMT_THIDA  (Q3SKJ2), PIMT_XANP2  (A7INP1)
» more

UniProtKB/Swiss-Prot
False positive sequences
1 sequence

CSPL2_PICSI (A9NTU2)

		
PDB
[Detailed view]
12 PDB

pdb_00001dl5; pdb_00001i1n; pdb_00001jg1; pdb_00001jg2; pdb_00001jg3; pdb_00001jg4; pdb_00001kr5; pdb_00001r18; pdb_00002yxe; pdb_00003lbf; pdb_00004l7v; pdb_00004o29