PROSITE documentation PDOC00991
TSC-22 / dip / bun family signature


The following eukaryotic proteins are evolutionary related and are thought to be involved in transcriptional regulation.

  • Vertebrate protein TSC-22 [1]. This protein of 144 residues seems to act a transcriptional regulator on C-type natriuretic peptide (CNP) promoter.
  • Mammalian protein DIP (DSIP-immunoreactive peptide) [2], a protein of 77 amino acids, whose function is not yet known.
  • Drosophila protein bunched [3] (gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.
  • Caenorhabditis elegans hypothetical protein T18D3.7.

These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerization. As a signature pattern we selected a highly conserved stretch of residues that is located just in front of the leucine zipper.

Last update:

November 1997 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

TSC22, PS01289; TSC-22 / dip / bun family signature  (PATTERN)


1AuthorsOhta S. Shimekake Y. Nagata K.
TitleMolecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter.
SourceEur. J. Biochem. 242:460-466(1996).
PubMed ID9022669

2AuthorsVogel P. Maegert H.J. Cieslak A. Adermann K. Forssmann W.-G.
TitlehDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues.
SourceBiochim. Biophys. Acta 1309:200-204(1996).
PubMed ID8982256

3AuthorsTreisman J.E. Lai Z.C. Rubin G.M.
TitleShortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene.
SourceDevelopment 121:2835-2845(1995).
PubMed ID7555710

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)