PROSITE documentation PDOC00991TSC-22 / dip / bun family signature
Description
The following eukaryotic proteins are evolutionary related and are thought to be involved in transcriptional regulation.
- Vertebrate protein TSC-22 [1]. This protein of 144 residues seems to act a transcriptional regulator on C-type natriuretic peptide (CNP) promoter.
- Mammalian protein DIP (DSIP-immunoreactive peptide) [2], a protein of 77 amino acids, whose function is not yet known.
- Drosophila protein bunched [3] (gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.
- Caenorhabditis elegans hypothetical protein T18D3.7.
These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerization. As a signature pattern we selected a highly conserved stretch of residues that is located just in front of the leucine zipper.
Last update:November 1997 / First entry.
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Technical section
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References
| 1 | Authors | Ohta S. Shimekake Y. Nagata K. |
| Title | Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. | |
| Source | Eur. J. Biochem. 242:460-466(1996). | |
| PubMed ID | 9022669 |
| 2 | Authors | Vogel P. Maegert H.J. Cieslak A. Adermann K. Forssmann W.-G. |
| Title | hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues. | |
| Source | Biochim. Biophys. Acta 1309:200-204(1996). | |
| PubMed ID | 8982256 |
| 3 | Authors | Treisman J.E. Lai Z.C. Rubin G.M. |
| Title | Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene. | |
| Source | Development 121:2835-2845(1995). | |
| PubMed ID | 7555710 |
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