We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00991TSC-22 / dip / bun family signature
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00991
Description
The following eukaryotic proteins are evolutionary related and are thought to be involved in transcriptional regulation.
- Vertebrate protein TSC-22 [1]. This protein of 144 residues seems to act a transcriptional regulator on C-type natriuretic peptide (CNP) promoter.
- Mammalian protein DIP (DSIP-immunoreactive peptide) [2], a protein of 77 amino acids, whose function is not yet known.
- Drosophila protein bunched [3] (gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.
- Caenorhabditis elegans hypothetical protein T18D3.7.
These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerization. As a signature pattern we selected a highly conserved stretch of residues that is located just in front of the leucine zipper.
Last update:November 1997 / First entry.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Ohta S. Shimekake Y. Nagata K. |
| Title | Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. | |
| Source | Eur. J. Biochem. 242:460-466(1996). | |
| PubMed ID | 9022669 |
| 2 | Authors | Vogel P. Maegert H.J. Cieslak A. Adermann K. Forssmann W.-G. |
| Title | hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues. | |
| Source | Biochim. Biophys. Acta 1309:200-204(1996). | |
| PubMed ID | 8982256 |
| 3 | Authors | Treisman J.E. Lai Z.C. Rubin G.M. |
| Title | Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene. | |
| Source | Development 121:2835-2845(1995). | |
| PubMed ID | 7555710 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.