PROSITE documentation PDOC00996Dephospho-CoA kinase (DPCK) domain profile
Dephospho-coenzyme A kinase (DPCK) (EC 2.7.1.24) catalyzes the final step in coenzyme A (CoA) biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. DPCK is present in a wide range of organisms, including bacteria, fungi, plants and animals. Whereas bacterial DPCK is found in stand-alone form, mammalian DPCK is associated with another enzyme of the CoA biosynthetic pathway, phosphopantetheine adenylyltransferase (PPAT) (EC 2.7.7.3), in bifunctional coenzyme A synthase (CoA synthase) [1,2].
The DPCK domain contains an ATP/GTP-binding Walker A motif (P-loop) (see <PDOC00017>) in its N-terminal extremity. It is structurally similar to many nucleoside kinases and other P-loop-containing nucleotide triphosphate hydrolases, despite having negligible sequence similarity to these enzymes. The DPCK domain consists of five parallel β-strands flanked by α-helices (see <PDB:1JJV>) [1,2].
The profile we developed covers the entire DPCK domain.
Last update:June 2006 / Pattern removed, profile added and text revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Obmolova G. Teplyakov A. Bonander N. Eisenstein E. Howard A.J. Gilliland G.L. |
| Title | Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae. | |
| Source | J. Struct. Biol. 136:119-125(2001). | |
| PubMed ID | 11886213 | |
| DOI | 10.1006/jsbi.2001.4428 |
| 2 | Authors | O'Toole N. Barbosa J.A.R.G. Li Y. Hung L.-W. Matte A. Cygler M. |
| Title | Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli. | |
| Source | Protein Sci. 12:327-336(2003). | |
| PubMed ID | 12538896 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)