PROSITE documentation PDOC00999
FLAP/GST2/LTC4S family signature


The following mammalian proteins are evolutionary related [1]:

  • Leukotriene C4 synthase (EC (gene LTC4S), an enzyme that catalyzes the production of LTC4 from LTA4.
  • Microsomal glutathione S-transferase II (EC (GST-II) (gene GST2), an enzyme that can also produces LTC4 fron LTA4.
  • 5-lipoxygenase activating protein (gene FLAP), a protein that seems to be required for the activation of 5-lipoxygenase.

These are proteins of 150 to 160 residues that contain three transmembrane segments. As a signature pattern, we selected a conserved region between the first and second transmembrane domains.

Last update:

November 1997 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

FLAP_GST2_LTC4S, PS01297; FLAP/GST2/LTC4S family signature  (PATTERN)


1AuthorsJakobsson P.-J. Mancini J.A. Ford-Hutchinson A.W.
TitleIdentification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase.
SourceJ. Biol. Chem. 271:22203-22210(1996).
PubMed ID8703034

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