PROSITE documentation PDOC00999FLAP/GST2/LTC4S family signature
Description
The following mammalian proteins are evolutionary related [1]:
- Leukotriene C4 synthase (EC 4.4.1.20) (gene LTC4S), an enzyme that catalyzes the production of LTC4 from LTA4.
- Microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II) (gene GST2), an enzyme that can also produces LTC4 fron LTA4.
- 5-lipoxygenase activating protein (gene FLAP), a protein that seems to be required for the activation of 5-lipoxygenase.
These are proteins of 150 to 160 residues that contain three transmembrane segments. As a signature pattern, we selected a conserved region between the first and second transmembrane domains.
Last update:November 1997 / First entry.
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Technical section
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Reference
| 1 | Authors | Jakobsson P.-J. Mancini J.A. Ford-Hutchinson A.W. |
| Title | Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. | |
| Source | J. Biol. Chem. 271:22203-22210(1996). | |
| PubMed ID | 8703034 |
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