We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00999FLAP/GST2/LTC4S family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00999
Description
The following mammalian proteins are evolutionary related [1]:
- Leukotriene C4 synthase (EC 4.4.1.20) (gene LTC4S), an enzyme that catalyzes the production of LTC4 from LTA4.
- Microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II) (gene GST2), an enzyme that can also produces LTC4 fron LTA4.
- 5-lipoxygenase activating protein (gene FLAP), a protein that seems to be required for the activation of 5-lipoxygenase.
These are proteins of 150 to 160 residues that contain three transmembrane segments. As a signature pattern, we selected a conserved region between the first and second transmembrane domains.
Last update:November 1997 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Jakobsson P.-J. Mancini J.A. Ford-Hutchinson A.W. |
| Title | Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. | |
| Source | J. Biol. Chem. 271:22203-22210(1996). | |
| PubMed ID | 8703034 |
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