PROSITE documentation PDOC01000
Dihydrodipicolinate reductase signature


Dihydrodipicolinate reductase (EC catalyzes the second step in the biosynthesis of diaminopimelic acid and lysine, the NAD or NADP-dependent reduction of 2,3-dihydrodipicolinate into 2,3,4,5-tetrahydrodipicolinate. This enzyme is present in bacteria (gene dapB) and higher plants.

As a signature pattern we selected the best conserved region in this enzyme. It is located in the central section and is part of the substrate-binding region [1].

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

DAPB, PS01298; Dihydrodipicolinate reductase signature  (PATTERN)


1AuthorsScapin G. Blanchard J.S. Sacchettini J.C.
TitleThree-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
SourceBiochemistry 34:3502-3512(1995).
PubMed ID7893645

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