We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC01015Prolipoprotein diacylglyceryl transferase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC01015
Description
Prolipoprotein diacylglyceryl transferase [1] is the bacterial enzyme that catalyzes the first step in lipoprotein biogenesis, it transfers the n-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins. Prolipoprotein diacylglyceryl transferase (gene lgt) is an integral membrane protein.
As a signature pattern for this family, we selected a highly conserved region located in the central part of the protein.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Sankaran K. Wu H.C. |
| Title | Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol. | |
| Source | J. Biol. Chem. 269:19701-19706(1994). | |
| PubMed ID | 8051048 |
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