PROSITE documentation PDOC01029Diaminopimelate epimerase signature
Description
Diaminopimelate epimerase (EC 5.1.1.7) catalyzes the isomeriazation of L,L- to D,L-meso-diaminopimelate in the biosynthetic pathway leading from aspartate to lysine.
This enzyme is a protein of about 30 Kd. Two conserved cysteines seem [1] to function as the acid and base in the catalytic mechanism. As a signature pattern, we selected the region surrounding the first of these two active site cysteines.
Last update:April 2006 / Pattern revised.
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Technical section
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Reference
| 1 | Authors | Cirilli M. Zheng R. Scapin G. Blanchard J.S. |
| Title | Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase. | |
| Source | Biochemistry 37:16452-16458(1998). | |
| PubMed ID | 9843410 | |
| DOI | 10.1021/bi982138o |
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