PROSITE documentation PDOC01032
Cytochrome c oxidase subunit VIa signature


Cytochrome c oxidase (EC [1] is an oligomeric enzymatic complex which is a component of the respiratory chain complex and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. In addition to the three large subunits that form the catalytic center of the enzyme complex there are, in eukaryotes, a variable number of small polypeptidic subunits. One of these subunits is known as VIa in vertebrates and fungi. Mammals have two tissue-specific isoforms of VIa, a liver and a heart form. Only one form is found is fish [2].

A signature pattern for VIa was developed that is based on the best conserved part of the protein, a region located in its C-terminal section.

Last update:

July 1999 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

COX6A, PS01329; Cytochrome c oxidase subunit VIa signature  (PATTERN)


1AuthorsCapaldi R.A. Malatesta F. Darley-Usmar V.M.
TitleStructure of cytochrome c oxidase.
SourceBiochim. Biophys. Acta 726:135-148(1983).
PubMed ID6307356

2AuthorsHuttemann M. Exner S. Arnold S. Lottspeich F. Kadenbach B.
TitleThe cDNA sequences of cytochrome c oxidase subunit VIa from carp and rainbow trout suggest the absence of isoforms in fishes.
SourceBiochim. Biophys. Acta 1319:14-18(1997).
PubMed ID9107314

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