PROSITE documentation PDOC01032Cytochrome c oxidase subunit VIa signature
Cytochrome c oxidase (EC 1.9.3.1) [1] is an oligomeric enzymatic complex which is a component of the respiratory chain complex and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. In addition to the three large subunits that form the catalytic center of the enzyme complex there are, in eukaryotes, a variable number of small polypeptidic subunits. One of these subunits is known as VIa in vertebrates and fungi. Mammals have two tissue-specific isoforms of VIa, a liver and a heart form. Only one form is found is fish [2].
A signature pattern for VIa was developed that is based on the best conserved part of the protein, a region located in its C-terminal section.
Last update:July 1999 / First entry.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Capaldi R.A. Malatesta F. Darley-Usmar V.M. |
| Title | Structure of cytochrome c oxidase. | |
| Source | Biochim. Biophys. Acta 726:135-148(1983). | |
| PubMed ID | 6307356 |
| 2 | Authors | Huttemann M. Exner S. Arnold S. Lottspeich F. Kadenbach B. |
| Title | The cDNA sequences of cytochrome c oxidase subunit VIa from carp and rainbow trout suggest the absence of isoforms in fishes. | |
| Source | Biochim. Biophys. Acta 1319:14-18(1997). | |
| PubMed ID | 9107314 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)