PROSITE documentation PDOC01039
Ornithine decarboxylase antizyme signature


Ornithine decarboxylase antizyme (ODC-AZ) [1] binds to, and destabilizes, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC is then rapidly degraded. The expression of ODC-AZ requires programmed, ribosomal frameshifting which is modulated according to the cellular concentration of polyamines. High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein.

At least three forms of ODC-AZ exist in mammals [2] and the protein has been found in Drosophila (protein Gutfeeling), nematodes and Schizosaccharomyces pombe [3].

As a signature pattern, we selected a highly conserved region in the C-terminal part of these proteins.

Last update:

December 2001 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ODC_AZ, PS01337; Ornithine decarboxylase antizyme signature  (PATTERN)


1AuthorsMatsufuji S. Matsufuji T. Miyazaki Y. Murakami Y. Atkins J.F. Gesteland R.F. Hayashi S.-I.
TitleAutoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.
SourceCell 80:51-60(1995).
PubMed ID7813017

2AuthorsIvanov I.P. Rohrwasser A. Terreros D.A. Gesteland R.F. Atkins J.F.
TitleDiscovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3.
SourceProc. Natl. Acad. Sci. U.S.A. 97:4808-4813(2000).
PubMed ID10781085

3AuthorsIvanov I.P. Matsufuji S. Murakami Y. Gesteland R.F. Atkins J.F.
TitleConservation of polyamine regulation by translational frameshifting from yeast to mammals.
SourceEMBO J. 19:1907-1917(2000).
PubMed ID10775274

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)