PROSITE documentation PDOC01039Ornithine decarboxylase antizyme signature
Ornithine decarboxylase antizyme (ODC-AZ) [1] binds to, and destabilizes, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC is then rapidly degraded. The expression of ODC-AZ requires programmed, ribosomal frameshifting which is modulated according to the cellular concentration of polyamines. High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein.
At least three forms of ODC-AZ exist in mammals [2] and the protein has been found in Drosophila (protein Gutfeeling), nematodes and Schizosaccharomyces pombe [3].
As a signature pattern, we selected a highly conserved region in the C-terminal part of these proteins.
Last update:December 2001 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Matsufuji S. Matsufuji T. Miyazaki Y. Murakami Y. Atkins J.F. Gesteland R.F. Hayashi S.-I. |
| Title | Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme. | |
| Source | Cell 80:51-60(1995). | |
| PubMed ID | 7813017 |
| 2 | Authors | Ivanov I.P. Rohrwasser A. Terreros D.A. Gesteland R.F. Atkins J.F. |
| Title | Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 97:4808-4813(2000). | |
| PubMed ID | 10781085 | |
| DOI | 10.1073/pnas.070055897 |
| 3 | Authors | Ivanov I.P. Matsufuji S. Murakami Y. Gesteland R.F. Atkins J.F. |
| Title | Conservation of polyamine regulation by translational frameshifting from yeast to mammals. | |
| Source | EMBO J. 19:1907-1917(2000). | |
| PubMed ID | 10775274 | |
| DOI | 10.1093/emboj/19.8.1907 |
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