We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC01041SURF4 family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC01041
Description
The surfeit locus 4 gene (SURF4 or surf-4) encodes for a conserved integral eukaryotic membrane protein of about 270 to 300 amino-acid residues that seems to be located in the endoplasmic reticulum [1].
As a signature pattern, we selected a conserved region located in the C-terminal section and that seems to overlap with the beginning of the last transmembrane domain of these proteins.
Last update:July 1999 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Reeves J.E. Fried M. |
| Title | The surf-4 gene encodes a novel 30 kDa integral membrane protein. | |
| Source | Mol. Membr. Biol. 12:201-208(1995). | |
| PubMed ID | 7540914 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.