PROSITE documentation PDOC01045
Claudin family signature


The claudins [1] are a family of integral membrane proteins that are major components of tight junction (TJ) strands. There are at least 17 members of this family in mammals. The claudins are proteins of about 200 to 230 residues that contains four conserved transmembrane domains.

As signature pattern for this family, we selected a conserved region located in an extracellular loop between the first and second transmembrane regions.


The claudin family is evolutionary related to the PMP-22 family (see <PDOC00939>).

Expert(s) to contact by email:

Keen T.J.

Last update:

December 2001 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CLAUDIN, PS01346; Claudin family signature  (PATTERN)


1AuthorsMorita K. Furuse M. Fujimoto K. Tsukita S.
TitleClaudin multigene family encoding four-transmembrane domain protein components of tight junction strands.
SourceProc. Natl. Acad. Sci. U.S.A. 96:511-516(1999).
PubMed ID9892664

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