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	PROSITE documentation PDOC01045

Claudin family signature

The claudins [1] are a family of integral membrane proteins that are major components of tight junction (TJ) strands. There are at least 17 members of this family in mammals. The claudins are proteins of about 200 to 230 residues that contains four conserved transmembrane domains.

As signature pattern for this family, we selected a conserved region located in an extracellular loop between the first and second transmembrane regions.

Note:

The claudin family is evolutionary related to the PMP-22 family (see <PDOC00939>).

Expert(s) to contact by email:

Keen T.J.

Last update:

December 2001 / First entry.

PROSITE method (with tools and information) covered by this documentation:

CLAUDIN, PS01346; Claudin family signature  (PATTERN)

• Consensus pattern:
  [GN]-L-W-x(2)-C-x(7,9)-[STDENQH]-C
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 75
  • detected by PS01346: 75 (true positives)
  • undetected by PS01346: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01346:
  9 false positives.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01346
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01346
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01346
• View ligand binding statistics of PS01346
• Matching PDB structures: 3X29 4P79 5B2G [ALL]

1	Authors	Morita K. Furuse M. Fujimoto K. Tsukita S.
	Title	Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.
	Source	Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999).
	PubMed ID	9892664

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