|PROSITE documentation PDOC01048|
The bacterial ispF protein  catalyzes the fifth step of the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis; the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. It can also converts 4-diphosphocytidyl-2C-methyl-D-erythritol into 2C-methyl-D-erythritol 3,4-cyclophosphate and CMP.
In addition to bacterial ispF, this family also includes:
These are proteins of around 20 kDa whose sequence is well conserved. As a signature pattern, we selected a well conserved region located in the N-terminal part of these proteins.Last update:
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Rohdich F. Wungsintaweekul J. Fellermeier M. Sagner S. Herz S. Kis K. Eisenreich W. Bacher A. Zenk M.H.|
|Title||Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 96:11758-11763(1999).|