PROSITE documentation PDOC010482C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature
The bacterial ispF protein [1] catalyzes the fifth step of the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis; the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. It can also converts 4-diphosphocytidyl-2C-methyl-D-erythritol into 2C-methyl-D-erythritol 3,4-cyclophosphate and CMP.
In addition to bacterial ispF, this family also includes:
- Plasmodium falciparum hypothetical protein PfB0420W.
These are proteins of around 20 kDa whose sequence is well conserved. As a signature pattern, we selected a well conserved region located in the N-terminal part of these proteins.
Last update:April 2006 / Pattern revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Rohdich F. Wungsintaweekul J. Fellermeier M. Sagner S. Herz S. Kis K. Eisenreich W. Bacher A. Zenk M.H. |
| Title | Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 96:11758-11763(1999). | |
| PubMed ID | 10518523 |
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