PROSITE documentation PDOC01048
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature


The bacterial ispF protein [1] catalyzes the fifth step of the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis; the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. It can also converts 4-diphosphocytidyl-2C-methyl-D-erythritol into 2C-methyl-D-erythritol 3,4-cyclophosphate and CMP.

In addition to bacterial ispF, this family also includes:

  • Plasmodium falciparum hypothetical protein PfB0420W.

These are proteins of around 20 kDa whose sequence is well conserved. As a signature pattern, we selected a well conserved region located in the N-terminal part of these proteins.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ISPF, PS01350; 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature  (PATTERN)


1AuthorsRohdich F. Wungsintaweekul J. Fellermeier M. Sagner S. Herz S. Kis K. Eisenreich W. Bacher A. Zenk M.H.
TitleCytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.
SourceProc. Natl. Acad. Sci. U.S.A. 96:11758-11763(1999).
PubMed ID10518523

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