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PROSITE documentation PDOC50032 |
Members of the KIN2/PAR-1/MARK kinase subfamily are conserved from yeast to human and share the same domain organisation: an N-terminal kinase domain and a C-terminal kinase associated domain 1 (KA1). Some members of the KIN1/PAR-1/MARK family also contain an UBA domain (see <PDOC50030>). Members of this kinase subfamily are involved in various biological processes such as cell polarity, cell cycle control, intracellular signaling, microtubule stability and protein stability [1]. The function of the KA1 domain is not yet known.
Some proteins known to contain a KA1 domain are listed below:
The profile we developed covers the entire KA1 domain.
Last update:June 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Tassan J.P. Le Goff X. |
Title | An overview of the KIN1/PAR-1/MARK kinase family. | |
Source | Biol. Cell 96:193-199(2004). | |
PubMed ID | 15182702 | |
DOI | 10.1016/j.biolcel.2003.10.009 |
2 | Authors | Biernat J. Wu Y.Z. Timm T. Zheng-Fischhofer Q. Mandelkow E. Meijer L. Mandelkow E.M. |
Title | Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. | |
Source | Mol. Biol. Cell 13:4013-4028(2002). | |
PubMed ID | 12429843 | |
DOI | 10.1091/mbc.02-03-0046 |
3 | Authors | Guo S. Kemphues K.J. |
Title | par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. | |
Source | Cell 81:611-620(1995). | |
PubMed ID | 7758115 |
4 | Authors | Elbert M. Rossi G. Brennwald P. |
Title | The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery. | |
Source | Mol. Biol. Cell 16:532-549(2005). | |
PubMed ID | 15563607 | |
DOI | 10.1091/mbc.E04-07-0549 |