PROSITE documentation PDOC50095

PLAT domain profile





Description

The PLAT domain (after polycystin-1, lipoxygenase and α toxin) is an intracellular domain of ~150 residues. The PLAT domain can be found associated with other domains such as LRR, PKD (see <PDOC50093>), C-type lectin (see <PDOC00537>), GPS (see <PDOC50221>), lipase, lipoxygenase (see <PDOC00077>) prokaryotic zinc-dependent phospholipase C (see <PDOC00357>), LCCL (see <PDOC50820>) or SRCR (see <PDOC00348>), It has been proposed that the PLAT domain may be involved in protein-protein and protein-lipid interaction [1,2].

The three-dimensional structure of the PLAT domain is known for several proteins. The domain is a β-sandwich composed of two sheets of four strands each (see <PDB:1LOX>). The most highly conserved regions of the PLAT domain coincide with the β-strands. Most of the highly conserved residues are buried residues. An exception to this is a surface lysine or arginine that occurs on the surface of the fifth β-strand of all eukaryotic PLAT domains. In pancreatic lipase, the lysine in this position forms a salt bridge with the procolipase protein. The conservation of a charged surface residue may indicate the location of a conserved ligand-binding site within the PLAT domain [1].

Some proteins known to contain a PLAT domain are listed below:

  • Animal polycystin-1 (PKD1). It may be an ion-channel. In human, defects in PKD1 are the cause of autosomal dominant polycystic kidney disease type I (ADPKD) that is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occur in the liver and other organs.
  • Eukaryotic lipoxygenase.
  • Vertebrate lipoprotein lipase.
  • Mammalian triacylglycerol lipase.
  • Plasmodium falciparum PSLAP protein, a protein with multiple adhesive motifs that is expressed in gametocytes [2].
  • Plasmodium berghei multidomain scavenger receptor protein PbSR.
  • Bacterial α toxin.

The profile we developed covers the entire PLAT domain.

Last update:

April 2003 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PLAT, PS50095; PLAT domain profile  (MATRIX)


References

1AuthorsBateman A., Sandford R.
TitleThe PLAT domain: a new piece in the PKD1 puzzle.
SourceCurr. Biol. 9:R588-R590(1999).
PubMed ID10469604

2AuthorsDelrieu I., Waller C.C., Mota M.M., Grainger M., Langhorne J., Holder A.A.
TitlePSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes.
SourceMol. Biochem. Parasitol. 121:11-20(2002).
PubMed ID11985859



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