PROSITE documentation PDOC50138BRCA2 repeat profile
The BRCA2 repeat [1] is a small domain (34 residues) currently found only in the breast cancer susceptibility gene protein 2 (BRCA2). These repeats were shown to be required for direct interaction with DNA repair protein RAD51 [2,3,4]. BRCA2 was also shown to functionally interact with p53 and RAD51 two key components of the cell cycle control and DNA repair pathways [5]. As BRCA1 and BRCA2 display a stable interaction both together [6] and with RAD51 [2,3,4,5,7], they may participate in a pathway associated with the activation of double-strand break repair and/or homologous recombination.
Expert(s) to contact by email: Last update:December 2001 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Bork P. Blomberg N. Nilges M. |
| Title | Internal repeats in the BRCA2 protein sequence. | |
| Source | Nat. Genet. 13:22-23(1996). | |
| PubMed ID | 8673099 | |
| DOI | 10.1038/ng0596-22 |
| 2 | Authors | Wong A.K.C. Pero R. Ormonde P.A. Tavtigian S.V. Bartel P.L. |
| Title | RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. | |
| Source | J. Biol. Chem. 272:31941-31944(1997). | |
| PubMed ID | 9405383 |
| 3 | Authors | Katagiri T. Saito H. Shinohara A. Ogawa H. Kamada N. Nakamura Y. Miki Y. |
| Title | Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51. | |
| Source | Genes Chromosomes Cancer 21:217-222(1998). | |
| PubMed ID | 9523196 | |
| DOI | 10.1002/(SICI)1098-2264(199803)21:3<217::AID-GCC5>3.0.CO;2-2 |
| 4 | Authors | Chen P.L. Chen C.F. Chen Y. Xiao J. Sharp Z.D. Lee W.H. |
| Title | The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 95:5287-5292(1998). | |
| PubMed ID | 9560268 |
| 5 | Authors | Marmorstein L.Y. Ouchi T. Aaronson S.A. |
| Title | The BRCA2 gene product functionally interacts with p53 and RAD51. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 95:13869-13874(1998). | |
| PubMed ID | 9811893 |
| 6 | Authors | Scully R. Chen J. Plug A. Xiao Y. Weaver D. Feunteun J. Ashley T. Livingston D.M. |
| Title | Association of BRCA1 with Rad51 in mitotic and meiotic cells. | |
| Source | Cell 88:265-275(1997). | |
| PubMed ID | 9008167 |
| 7 | Authors | Chen J. Silver D.P. Walpita D. Cantor S.B. Gazdar A.F. Tomlinson G. Couch F.J. Weber B.L. Ashley T. Livingston D.M. Scully R. |
| Title | Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. | |
| Source | Mol. Cell 2:317-328(1998). | |
| PubMed ID | 9774970 |
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