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PROSITE documentation PDOC50138

BRCA2 repeat profile





Description

The BRCA2 repeat [1] is a small domain (34 residues) currently found only in the breast cancer susceptibility gene protein 2 (BRCA2). These repeats were shown to be required for direct interaction with DNA repair protein RAD51 [2,3,4]. BRCA2 was also shown to functionally interact with p53 and RAD51 two key components of the cell cycle control and DNA repair pathways [5]. As BRCA1 and BRCA2 display a stable interaction both together [6] and with RAD51 [2,3,4,5,7], they may participate in a pathway associated with the activation of double-strand break repair and/or homologous recombination.

Expert(s) to contact by email:

Falquet L.

Last update:

December 2001 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

BRCA2_REPEAT, PS50138; BRCA2 repeat profile  (MATRIX)


References

1AuthorsBork P. Blomberg N. Nilges M.
TitleInternal repeats in the BRCA2 protein sequence.
SourceNat. Genet. 13:22-23(1996).
PubMed ID8673099
DOI10.1038/ng0596-22

2AuthorsWong A.K.C. Pero R. Ormonde P.A. Tavtigian S.V. Bartel P.L.
TitleRAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
SourceJ. Biol. Chem. 272:31941-31944(1997).
PubMed ID9405383

3AuthorsKatagiri T. Saito H. Shinohara A. Ogawa H. Kamada N. Nakamura Y. Miki Y.
TitleMultiple possible sites of BRCA2 interacting with DNA repair protein RAD51.
SourceGenes Chromosomes Cancer 21:217-222(1998).
PubMed ID9523196
DOI10.1002/(SICI)1098-2264(199803)21:3<217::AID-GCC5>3.0.CO;2-2

4AuthorsChen P.L. Chen C.F. Chen Y. Xiao J. Sharp Z.D. Lee W.H.
TitleThe BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
SourceProc. Natl. Acad. Sci. U.S.A. 95:5287-5292(1998).
PubMed ID9560268

5AuthorsMarmorstein L.Y. Ouchi T. Aaronson S.A.
TitleThe BRCA2 gene product functionally interacts with p53 and RAD51.
SourceProc. Natl. Acad. Sci. U.S.A. 95:13869-13874(1998).
PubMed ID9811893

6AuthorsScully R. Chen J. Plug A. Xiao Y. Weaver D. Feunteun J. Ashley T. Livingston D.M.
TitleAssociation of BRCA1 with Rad51 in mitotic and meiotic cells.
SourceCell 88:265-275(1997).
PubMed ID9008167

7AuthorsChen J. Silver D.P. Walpita D. Cantor S.B. Gazdar A.F. Tomlinson G. Couch F.J. Weber B.L. Ashley T. Livingston D.M. Scully R.
TitleStable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
SourceMol. Cell 2:317-328(1998).
PubMed ID9774970



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