PROSITE entry PS50138
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General information about the entry
| Entry name [info] | BRCA2_REPEAT |
| Accession [info] | PS50138 |
| Entry type [info] | MATRIX |
| Date [info] |
01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50138 |
| Associated ProRule [info] | PRU00032 |
Name and characterization of the entry
| Description [info] | BRCA2 repeat profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=35; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=32; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.7467999; R2=0.0176268; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1499.0524902; R2=1.7651933; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=384; H_SCORE=2177; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=270; H_SCORE=1976; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='N'; M=-10, 4,-21, -8,-10, 6,-15, -8, -8, -6,-14, -9, 16,-20,-11, -6, 0, -3,-11,-23, -4,-10; /M: SY='E'; M= -1, 5,-25, 10, 36,-26,-15, 9,-26, 3,-20,-16, 1, -5, 13, -4, 5, -6,-24,-30,-15, 24; /M: SY='S'; M= -1, 0,-16, -5, -9,-15,-13,-13, -6,-10,-18,-11, 8, -5,-10,-11, 11, 10, -1,-35,-18,-10; /M: SY='S'; M= 6, -8,-16,-13,-13, -8, 9,-18,-19,-15,-18,-14, -1,-15,-14,-15, 14, 11,-10,-24,-14,-13; /M: SY='F'; M= -5,-13, -6,-14,-15, 4,-10,-19,-15,-20, -6,-10,-13,-10,-21,-20,-10,-10,-11,-20, -9,-18; /M: SY='G'; M= -5,-14,-24,-14,-11,-15, 3,-16,-15,-13, -6, -8, -9, -6,-11, -6, -3, -1,-13,-25,-16,-13; /M: SY='G'; M= 10,-14,-21,-19,-18, -9, 18,-20,-14,-19,-14,-10, -6,-18,-18,-20, 3, -8, -9,-19,-15,-18; /M: SY='F'; M=-20,-30,-20,-40,-30, 80,-30,-20, 0,-30, 10, 0,-20,-30,-40,-20,-20,-10, 0, 10, 30,-30; /M: SY='H'; M=-11, -8,-25, -8, -3,-10,-18, 16,-19, 3,-18, -8, -1,-19, 9, 14, 1, -4,-18,-14, 14, 0; /M: SY='T'; M= 0, -4,-13,-13,-11,-10,-20,-20, -4,-13, -9, -8, -1,-11,-10,-13, 18, 39, 3,-30,-10,-11; /M: SY='A'; M= 45, -9,-10,-18, -9,-20, 0,-19,-11,-10,-13,-11, -8,-10, -9,-19, 14, 3, -1,-23,-20, -9; /M: SY='S'; M= 4, -3, 4, -4, -4,-20, -6, 1,-23,-13,-28,-18, 6,-15, -3,-11, 28, 11,-13,-40,-16, -4; /M: SY='G'; M= 0, -3,-26, -5,-15,-28, 53,-15,-35,-16,-30,-20, 9,-19,-15,-16, 6,-13,-28,-25,-28,-15; /M: SY='K'; M=-10, -1,-28, -3, 6,-26,-20,-10,-28, 40,-26,-10, 0,-11, 8, 30, -6, -3,-18,-21,-10, 6; /M: SY='K'; M= -8, 3,-26, 0, 10,-25,-18, -6,-16, 16,-21, -9, 6,-11, 11, 8, 0, -5,-16,-26,-13, 10; /M: SY='V'; M= -6,-24,-19,-28,-23, -3,-30,-24, 21,-16, 11, 9,-20,-24,-19,-10,-11, 1, 25,-25, -6,-23; /M: SY='S'; M= -3, 1,-20, -1, 3,-21,-11, -6,-18, 6,-19,-10, 8,-14, 8, 3, 10, 3,-15,-30,-14, 5; /M: SY='V'; M= -5,-29, 0,-33,-29, -1,-33,-29, 26,-25, 14, 10,-26,-29,-26,-24,-15, -5, 33,-29, -9,-29; /M: SY='S'; M= 18, -6,-11, -9, -5,-16, -4,-14,-13,-13,-15,-13, 0,-13, -5,-14, 24, 11, -5,-33,-18, -5; /M: SY='E'; M=-11, 9,-28, 13, 21,-29,-19, 9,-28, 14,-23,-13, 4, -9, 15, 6, -1, -4,-24,-28,-10, 18; /M: SY='E'; M= 0, 4,-23, 6, 28,-24,-15, 6,-24, 0,-19,-15, 1, -6, 9, -5, 8, 1,-20,-30,-14, 18; /M: SY='S'; M= 9, 0,-13, -5, -5,-15, -6,-11,-13,-11,-15,-13, 8,-14, -5,-11, 21, 15, -8,-34,-16, -5; /M: SY='L'; M=-11,-30,-23,-34,-24, 16,-33,-23, 25,-30, 38, 18,-26,-28,-23,-23,-26,-10, 14,-16, 4,-24; /M: SY='Q'; M=-13, 8,-28, 8, 8,-26,-18, 11,-21, 10,-16, -6, 8,-15, 16, 6, -6,-10,-23,-26, -8, 11; /M: SY='K'; M=-10, 6,-29, 5, 15,-29,-18, -6,-29, 39,-29,-13, 8,-10, 10, 23, -6, -9,-23,-24,-13, 13; /M: SY='V'; M= 19,-19,-13,-24,-19,-10,-16,-24, 11,-16, -1, 0,-16,-19,-18,-20, 3, 1, 21,-26,-14,-19; /M: SY='K'; M= -9, -9,-25, -9, -1,-21,-23,-14,-15, 30,-19, -5, -8,-16, 0, 23,-10, -8, -3,-23,-10, -1; /M: SY='N'; M=-10, 13,-26, 9, 3,-26, -3, -1,-23, 10,-23, -6, 15,-15, 8, 4, -3, -9,-23,-28,-15, 5; /M: SY='F'; M=-11,-31,-23,-35,-28, 24,-30,-25, 16,-26, 18, 8,-28,-29,-28,-21,-23,-10, 15, 6, 9,-26; /M: SY='F'; M=-18,-30,-20,-38,-28, 63,-30,-20, 5,-30, 20, 5,-23,-30,-35,-20,-23,-10, 3, 3, 23,-28; /M: SY='D'; M= -8, 13,-23, 18, 13,-26,-13, -6,-28, 8,-25,-19, 8,-10, 4, 6, 10, 5,-19,-33,-16, 8; /M: SY='E'; M=-14, 24,-30, 36, 40,-35,-16, 1,-33, 6,-24,-21, 8, -5, 18, -3, 0,-10,-30,-33,-19, 29; /M: SY='I'; M= -9,-17,-26,-23,-14, 0,-27,-20, 10, -4, -3, 3,-10,-17,-11, -9, -9, -6, 6,-19, -1,-14; /M: SY='E'; M=-13, 6,-30, 14, 33,-16,-20, -6,-26, 0,-19,-19, -3, 7, 4, -7, -4,-10,-26,-26,-14, 19; /M: SY='E'; M= -9, 11,-24, 14, 20,-24,-14, -1,-20, -1,-14,-13, 9,-11, 11, -4, 3, -4,-21,-31,-16, 16; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 35 in 9 different sequences |
| Number of true positive hits | 35 in 9 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 8 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Feature key [info] | REPEAT |
| Feature description [info] | BRCA2 |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
9 sequences
BRC2A_ARATH (Q7Y1C5), BRC2B_ARATH (Q7Y1C4), BRCA2_DROME (Q9W157), BRCA2_DROSE (B4IH30), BRCA2_DROSI (B4QC10), BRCA2_FELCA (Q864S8), BRCA2_HUMAN (P51587), BRCA2_MOUSE (P97929), BRCA2_RAT (O35923)» more
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| PDB [Detailed view] |
5 PDB
1N0W; 6HQU; 8BR9; 8C3J; 8C3N |