PROSITE documentation PDOC50158Zinc finger CCHC-type profile
Description
The 18 residues CCHC zinc finger is mainly found in the nucleocapsid protein of retrovirus. It is required for viral genome packaging and for early infection process [1,2]. It is also found in eukaryotic proteins involved in RNA binding or single-stranded DNA binding.
Some proteins known to contain a CCHC zinc finger are listed below.
- Retroviral GAG protein. Nucleocapside protein.
- Human CNBP protein. CNBP is involved in sterol-mediated repression. It has also been shown to bind the 5' untranslated region of ribosomal proteins mRNA (a region known to be important in translational regulation).
- Yeast BYR3; the CNBP homolog.
- Caenorhabditis elegans protein glh-1; a probable ATP-binding RNA helicase.
- Leishmania major hexamer-binding protein (HEXP). It binds the 5' untranslated region of the GP63 gene.
- Tobbacco transposon TNT1 PolX protein. Retrovirus-related pol polyprotein.
The profile we developed covers the whole domain.
Last update:January 2002 / First entry.
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Technical section
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References
| 1 | Authors | Katz R.A. Jentoft J.E. |
| Title | What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins? | |
| Source | BioEssays 11:176-181(1989). | |
| PubMed ID | 2695083 |
| 2 | Authors | Urbaneja M.A. Kane B.P. Johnson D.G. Gorelick R.J. Henderson L.E. Casas-Finet J.R. |
| Title | Binding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: elucidation of the structural determinants for function. | |
| Source | J. Mol. Biol. 287:59-75(1999). | |
| PubMed ID | 10074407 |
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