We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC50158Zinc finger CCHC-type profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50158
Description
The 18 residues CCHC zinc finger is mainly found in the nucleocapsid protein of retrovirus. It is required for viral genome packaging and for early infection process [1,2]. It is also found in eukaryotic proteins involved in RNA binding or single-stranded DNA binding.
Some proteins known to contain a CCHC zinc finger are listed below.
- Retroviral GAG protein. Nucleocapside protein.
- Human CNBP protein. CNBP is involved in sterol-mediated repression. It has also been shown to bind the 5' untranslated region of ribosomal proteins mRNA (a region known to be important in translational regulation).
- Yeast BYR3; the CNBP homolog.
- Caenorhabditis elegans protein glh-1; a probable ATP-binding RNA helicase.
- Leishmania major hexamer-binding protein (HEXP). It binds the 5' untranslated region of the GP63 gene.
- Tobbacco transposon TNT1 PolX protein. Retrovirus-related pol polyprotein.
The profile we developed covers the whole domain.
Last update:January 2002 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Katz R.A. Jentoft J.E. |
| Title | What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins? | |
| Source | BioEssays 11:176-181(1989). | |
| PubMed ID | 2695083 |
| 2 | Authors | Urbaneja M.A. Kane B.P. Johnson D.G. Gorelick R.J. Henderson L.E. Casas-Finet J.R. |
| Title | Binding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: elucidation of the structural determinants for function. | |
| Source | J. Mol. Biol. 287:59-75(1999). | |
| PubMed ID | 10074407 |
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