|PROSITE documentation PDOC50179|
The VHS domain is an about 150 residues long domain, whose name is derived from its occurrence in VPS-27, Hrs and STAM. The VHS domain is found at the N-termini of proteins associated with endocytocis and/or vesicular trafficking, often in association with other domains like FYVE (see <PDOC50178>), SH3 (see <PDOC50002>) or TAM [1,2]. The VHS domain of Hrs makes both intra- and intermolecular interactions with FYVE domains and it has been proposed that it might as well interact with other domains. The VHS domain might function as a multipurpose docking adapter that localizes proteins to the membrane through interactions with the membrane and/or the endocytic machinery [3,4].
Some proteins known to contain a VHS domain are listed below:
The profile we developed covers the entire VHS domain.Last update:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Schultz J. Milpetz F. Bork P. Ponting C.P.|
|Title||SMART, a simple modular architecture research tool: identification of signaling domains.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 95:5857-5864(1998).|
|2||Authors||Lohi O. Lehto V.-P.|
|Title||VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking.|
|Source||FEBS Lett. 440:255-257(1998).|
|3||Authors||Mao Y. Nickitenko A. Duan X. Lloyd T.E. Wu M.N. Bellen H. Quiocho F.A.|
|Title||Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction.|
|4||Authors||Misra S. Beach B.M. Hurley J.H.|
|Title||Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes.|