We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC50244Steroid 5-alpha reductase C-terminal domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50244
Description
Steroid 5-α reductases (EC 1.3.99.5) are responsible for the NADPH-dependent reduction of testosterone into dihydrotestosterone, a key reaction in androgen action [1]. This enzyme is also found in plants where it is involved in brassinosteroids biosynthesis [2]. A domain of around 80 amino acids is found in the C-terminal part of the protein and contains the binding site for NADPH [3].
Last update:April 2002 / First entry.
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Technical section
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References
| 1 | Authors | Russell D.W. Wilson J.D. |
| Title | Steroid 5 alpha-reductase: two genes/two enzymes. | |
| Source | Annu. Rev. Biochem. 63:25-61(1994). | |
| PubMed ID | 7979239 | |
| DOI | 10.1146/annurev.bi.63.070194.000325; |
| 2 | Authors | Li J. Biswas M.G. Chao A. Russell D.W. Chory J. |
| Title | Conservation of function between mammalian and plant steroid 5alpha-reductases. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 94:3554-3559(1997). | |
| PubMed ID | 9108014 |
| 3 | Authors | Bhattacharyya A.K. Chavan A.J. Haley B.E. Taylor M.F. Collins D.C. |
| Title | Identification of the NADP(H) binding site of rat liver microsomal 5 alpha-reductase (isozyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain. | |
| Source | Biochemistry 34:3663-3669(1995). | |
| PubMed ID | 7893662 |
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