|PROSITE documentation PDOC50826|
The RUN domain, named after RPIP8, unc-14 and NESCA, is organized into six conserved blocks (A-F), which are predicted to constitute the 'core' of a globular structure tolerating insertions of considerable length between the conserved blocks. The RUN domain is found in one or two copies in several proteins that are linked particularly to the functions of GTPases in the Rap and Rab families. RUN domains can be associated with TBC/rab GAP (see <PDOC50086>), FYVE (see <PDOC50178>), DENN, SH3 (see <PDOC50002>), DAG/PE-binding (see <PDOC00379>), PLAT/LH2, PH (see <PDOC50003>) or PX (see <PDOC50195>) domains. The RUN domain may have a role in the interaction of various proteins with cytoskeletal filaments .
The predicted secondary structures of the RUN domain core indicate a predominantly α fold .
Some proteins known to contain a RUN domain are listed below:
The profile we developed covers the entire RUN domain.Last update:
April 2003 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Callebaut I. de Gunzburg J. Goud B. Mornon J.-P.|
|Title||RUN domains: a new family of domains involved in Ras-like GTPase signaling.|
|Source||Trends Biochem. Sci. 26:79-83(2001).|
|2||Authors||Mari M. Macia E. Le Marchand-Brustel Y. Cormont M.|
|Title||Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4.|
|Source||J. Biol. Chem. 276:42501-42508(2001).|