PROSITE documentation PDOC50828Smr domain profile
Description
The Smr domain is an around 90-residue domain found in:
- The C-terminal region of the mutS2 proteins from bacteria and plants,
- The small mutS related (smr) proteins from bacteria and eukaryotes.
These proteins could be involved in mismatch repair (MMR) or/and chromosome crossing-over and segregation. It has been proposed that the Smr domain acts as a nicking endonuclease [1,2].
The profile we developed spans the entire Smr domain.
Last update:March 2004 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Moreira D. Philippe H. |
| Title | Smr: a bacterial and eukaryotic homologue of the C-terminal region of the MutS2 family. | |
| Source | Trends Biochem. Sci. 24:298-300(1999). | |
| PubMed ID | 10431172 |
| 2 | Authors | Malik H.S. Henikoff S. |
| Title | Dual recognition-incision enzymes might be involved in mismatch repair and meiosis. | |
| Source | Trends Biochem. Sci. 25:414-418(2000). | |
| PubMed ID | 10973051 |
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