PROSITE documentation PDOC50828
Smr domain profile


The Smr domain is an around 90-residue domain found in:

  • The C-terminal region of the mutS2 proteins from bacteria and plants,
  • The small mutS related (smr) proteins from bacteria and eukaryotes.

These proteins could be involved in mismatch repair (MMR) or/and chromosome crossing-over and segregation. It has been proposed that the Smr domain acts as a nicking endonuclease [1,2].

The profile we developed spans the entire Smr domain.

Last update:

March 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SMR, PS50828; Smr domain profile  (MATRIX)


1AuthorsMoreira D. Philippe H.
TitleSmr: a bacterial and eukaryotic homologue of the C-terminal region of the MutS2 family.
SourceTrends Biochem. Sci. 24:298-300(1999).
PubMed ID10431172

2AuthorsMalik H.S. Henikoff S.
TitleDual recognition-incision enzymes might be involved in mismatch repair and meiosis.
SourceTrends Biochem. Sci. 25:414-418(2000).
PubMed ID10973051

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)