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PROSITE documentation PDOC50828

Smr domain profile





Description

The Smr domain is an around 90-residue domain found in:

  • The C-terminal region of the mutS2 proteins from bacteria and plants,
  • The small mutS related (smr) proteins from bacteria and eukaryotes.

These proteins could be involved in mismatch repair (MMR) or/and chromosome crossing-over and segregation. It has been proposed that the Smr domain acts as a nicking endonuclease [1,2].

The profile we developed spans the entire Smr domain.

Last update:

March 2004 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

SMR, PS50828; Smr domain profile  (MATRIX)


References

1AuthorsMoreira D. Philippe H.
TitleSmr: a bacterial and eukaryotic homologue of the C-terminal region of the MutS2 family.
SourceTrends Biochem. Sci. 24:298-300(1999).
PubMed ID10431172

2AuthorsMalik H.S. Henikoff S.
TitleDual recognition-incision enzymes might be involved in mismatch repair and meiosis.
SourceTrends Biochem. Sci. 25:414-418(2000).
PubMed ID10973051



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