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PROSITE documentation PDOC50833Brix domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50833
Analysis of the Brix (biogenesis of ribosomes in Xenopus) protein leaded to the identification of a region of 150-180 residues length, called the Brix domain, which is found in six protein families: one archaean family (I) including hypothetical proteins (one per genome); and five eukaryote families, each named according to a representative member and including close homologues of this prototype: (II) Peter Pan (D. melanogaster) and SSF1/2 (S.cerevisiae); (III) RPF1 (S. cerevisiae); (IV) IMP4 (S. cerevisiae); (V) Brix (X.laevis) and BRX1 (S. cerevisiae); and (VI) RPF2 (S.cerevisiae).
Typically, a protein sequence belonging to the Brix domain superfamily contains a highly charged N-terminal segment (about 50 residues) followed by a single copy of the Brix domain and another highly charged C-terminal region (about 100 residues). The archaean sequences have two unique characteristics: (1) the charged regions are totally absent at the N-terminus and are reduced in number to about 10 residues at the C-terminus; and (2) the C-terminal part of the Brix domain itself is minimal. Two eukaryote groups have large insertions within the C-terminal region: about 70 residues in the group III and about 120 in the group II. Biological data for some proteins in this family suggest a role in ribosome biogenesis and rRNA binding [1,2].
The profile we developed spans the entire Brix domain.
Last update:August 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Eisenhaber F. Wechselberger C. Kreil G. |
| Title | The Brix domain protein family -- a key to the ribosomal biogenesis pathway? | |
| Source | Trends Biochem. Sci. 26:345-347(2001). | |
| PubMed ID | 11406393 |
| 2 | Authors | Mayer C. Suck D. Poch O. |
| Title | The archaeal homolog of the Imp4 protein, a eukaryotic U3 snoRNP component. | |
| Source | Trends Biochem. Sci. 26:143-144(2001). | |
| PubMed ID | 11246005 |
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