|PROSITE documentation PDOC50834|
Interferons (IFNs) are cytokines that regulate host resistance against infections by exerting antimicrobial, immunomodulatory and cell growth regulatory functions. Following their binding to specific cell surface receptors, they induce the expression of a defined set of genes that elicit a number of cellular responses. The HIN-200 (hematopoietic interferon-inducible nuclear proteins with a 200-amino-acid repeat) gene family found on human and mouse chromosome 1 is positively regulated by INFs. The murine HIN-200 gene family consists of at least four members designated 202, 203, 204, and D3, while the human HIN-200 family members include IFI16, the myeloid nuclear differentiation antigen (MNDA), and AIM-2 (absent in melanoma 2). All proteins encoded by these genes translocate to the nucleus following induction of expression by INFs. HIN-200 proteins play a role in modulating cell growth and perhaps in vivo differentiation. Some family members are transcriptional regulators, acting either directly by binding DNA or indirectly by modulating the function of other cellular transcription factors. They are hydrophilic proteins lacking signal sequences and transmembrane region. All the proteins belonging to the HIN-200 family contain one or two 200 amino acid long conserved motifs, designated as the type A and type B domains, in addition to other regions that are different or missing among the various family members. These 200-amino-acid regions are unique to the HIN-200 proteins and contain no known functional motifs that could provide some clue to their physiological relevance. However, there are stretches of amino acids, such as the sequence MFHATVAT, that exhibit almost complete identity across the A and B domains of all family members. Altough the function of the HIN-200 domains A and B is not known, it has been shown that the inhibition of cell growth by some HIN-200 proteins requires both domains [1,2,3,4].
The profile we developed covers the entire HIN-200 domain.Last update:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Dawson M.J. Trapani J.A.|
|Title||HIN-200: a novel family of IFN-inducible nuclear proteins expressed in leukocytes.|
|Source||J. Leukoc. Biol. 60:310-316(1996).|
|2||Authors||Landolfo S. Gariglio M. Gribaudo G. Lembo D.|
|Title||The Ifi 200 genes: an emerging family of IFN-inducible genes.|
|3||Authors||Johnstone R.W. Trapani J.A.|
|Title||Transcription and growth regulatory functions of the HIN-200 family of proteins.|
|Source||Mol. Cell. Biol. 19:5833-5838(1999).|
|4||Authors||Gribaudo G. Riera L. De Andrea M. Landolfo S.|
|Title||The antiproliferative activity of the murine interferon-inducible Ifi 200 proteins depends on the presence of two 200 amino acid domains.|
|Source||FEBS Lett. 456:31-36(1999).|