PROSITE documentation PDOC50858
BSD domain profile


The BSD domain is an about 60-residue long domain named after the BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins in which it is found. Additionally, it is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of species ranging from primal protozoan to human. It can be found associated with other domains such as the BTB domain (see <PDOC50097>) or the U-box in multidomain proteins. The function of the BSD domain is yet unknown [1].

Secondary structure prediction indicates the presence of three predicted α helices, which probably form a three-helical bundle in small domains. The third predicted helix contains neighboring phenylalanine and tryptophan residues - less common amino acids that are invariant in all the BSD domains identified and that are the most striking sequence features of the domain [1].

Some proteins known to contain one or two BSD domains are listed below:

  • Mammalian TFIIH basal transcription factor complex p62 subunit (GTF2H1).
  • Yeast RNA polymerase II transcription factor B 73 kDa subunit (TFB1), the homologue of BTF2.
  • Yeast DOS2 protein. It is involved in single-copy DNA replication and ubiquitination.
  • Drosophila synapse-associated protein SAP47.
  • Mammalian SYAP1.
  • Various Arabidopsis thaliana hypothetical proteins.

The profile we developed covers the entire BSD domain.

Last update:

May 2003 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

BSD, PS50858; BSD domain profile  (MATRIX)


1AuthorsDoerks T. Huber S. Buchner E. Bork P.
TitleBSD: a novel domain in transcription factors and synapse-associated proteins.
SourceTrends Biochem. Sci. 27:168-170(2002).
PubMed ID11943536

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