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PROSITE documentation PDOC50858BSD domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50858
The BSD domain is an about 60-residue long domain named after the BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins in which it is found. Additionally, it is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of species ranging from primal protozoan to human. It can be found associated with other domains such as the BTB domain (see <PDOC50097>) or the U-box in multidomain proteins. The function of the BSD domain is yet unknown [1].
Secondary structure prediction indicates the presence of three predicted α helices, which probably form a three-helical bundle in small domains. The third predicted helix contains neighboring phenylalanine and tryptophan residues - less common amino acids that are invariant in all the BSD domains identified and that are the most striking sequence features of the domain [1].
Some proteins known to contain one or two BSD domains are listed below:
- Mammalian TFIIH basal transcription factor complex p62 subunit (GTF2H1).
- Yeast RNA polymerase II transcription factor B 73 kDa subunit (TFB1), the homologue of BTF2.
- Yeast DOS2 protein. It is involved in single-copy DNA replication and ubiquitination.
- Drosophila synapse-associated protein SAP47.
- Mammalian SYAP1.
- Various Arabidopsis thaliana hypothetical proteins.
The profile we developed covers the entire BSD domain.
Last update:May 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Doerks T. Huber S. Buchner E. Bork P. |
| Title | BSD: a novel domain in transcription factors and synapse-associated proteins. | |
| Source | Trends Biochem. Sci. 27:168-170(2002). | |
| PubMed ID | 11943536 |
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