PROSITE documentation PDOC50863B3 DNA-binding domain profile
The B3 domain is an about 120-amino acid residue region defined originally as the third basic region of maize VP1, which shares the largest contiguous block of sequence identity with its ortholog, Arabidopsis ABI3. The B3 domain, which has also been called REM domain, is found only in higher plant species. It is characteristic of several transcription factors and has been shown to possess a highly cooperative, sequence-specific DNA-binding activity [1,2,3,4]. The B3 domain can be found in one or more copies and in association with other domains, such as the AP2 DNA-binding domain, an acidic domain or the Aux/IAA-ARF domain (see <PDOC51745>) [2,4].
Some proteins known to contain a B3 domain are listed below:
- Plant REPRODUCTIVE MERISTEM 1 (REM1) protein.
- Plant ABSCISIC ACID-INSENSITIVE 3 (ABI3)/VIVIPAROUS1 (VP1) family of regulatory protein.
- Arabidopsis thaliana proteins related to ABI3/VP1 RAV1 and RAV2.
- Arabidopsis thaliana AUXIN RESPONSE FACTOR 1 (ARF1).
- Arabidopsis thaliana FUSCA3 (FUS3).
- Arabidopsis thaliana LEAFY COTYLEDON 2 (LEC2).
The profile we developed covers the entire B3 domain.
Last update:March 2004 / First entry.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Suzuki M. Kao C.Y. McCarty D.R. |
| Title | The conserved B3 domain of VIVIPAROUS1 has a cooperative DNA binding activity. | |
| Source | Plant Cell 9:799-807(1997). | |
| PubMed ID | 9165754 | |
| DOI | 10.1105/tpc.9.5.799 |
| 2 | Authors | Kagaya Y. Ohmiya K. Hattori T. |
| Title | RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plants. | |
| Source | Nucleic Acids Res. 27:470-478(1999). | |
| PubMed ID | 9862967 |
| 3 | Authors | Stone S.L. Kwong L.W. Yee K.M. Pelletier J. Lepiniec L. Fischer R.L. Goldberg R.B. Harada J.J. |
| Title | LEAFY COTYLEDON2 encodes a B3 domain transcription factor that induces embryo development. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 98:11806-11811(2001). | |
| PubMed ID | 11573014 | |
| DOI | 10.1073/pnas.201413498 |
| 4 | Authors | Franco-Zorrilla J.M. Cubas P. Jarillo J.A. Fernandez-Calvin B. Salinas J. Martinez-Zapater J.M. |
| Source | Plant Physiol. 128:418-427(2002). |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)