PROSITE documentation PDOC50882
YTH domain profile


The YTH (for YT521-B homology) is a 100-150-residue domain that has been identified in the mammalian pre-mRNA splicing factor YT521-B and its Drosophila and yeast homologues. The YTH domain is found in a number of eukaryotic nuclear proteins of unknown function that could be involved in RNA binding. It is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence. It has been predicted that the biological function of the YTH domain is to bind to RNA [1].

The YTH domain is predicted to have a mixed α-helix-β-sheet fold, with four α-helices and six β-strands. The conservation pattern follows the predicted secondary structure, with three blocks of conserved sequence separated by loops of variable size. Notable features of the YTH domain are the highly conserved aromatic residues located in the β-sheet [1].

Some proteins known to contain a YTH domain are listed below:

  • Mammalian putative splicing factor YT521.
  • Human dermatomyositis associated with cancer putative autoantigen-1 (DACA- 1) and its mammalian homologs.
  • Human high-glucose-regulated protein 8 and its mammalian homologs.

The profile we developed covers the entire YTH domain.

Last update:

May 2003 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

YTH, PS50882; YTH domain profile  (MATRIX)


1AuthorsStoilov P. Rafalska I. Stamm S.
TitleYTH: a new domain in nuclear proteins.
SourceTrends Biochem. Sci. 27:495-497(2002).
PubMed ID12368078

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