Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC50908RWD domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50908
The RWD domain is a conserved region of about 110 amino acid residues, which has been identified in the mouse GCN2 eIF2α kinase and histidyl-tRNA synthetase and in presumed orthologs in other eukaryotic species from yeast to vertebrates. Additionally, it is also found in WD repeat containing proteins, yeast DEAD (DEXD)-like helicases, many RING-finger containing proteins, the UPF0029 uncharacterized protein family (see <PDOC00707>) and a range of hypothetical proteins. The RWD domain has been named after the better characterized RING finger (see <PDOC00449>) and WD repeat containing proteins (see <PDOC00574>) and DEAD-like helicaces (see <PDOC00039>). It has been proposed that the RWD domain might have a function in protein interaction [1].
The RWD domain is predicted to have an α/β secondary structure and is thought to be related to ubiquitin-conjugating enzymes (UBCc) domain, although the catalytic cysteine critical for ubiquitin-conjugating activity is not conserved in most members of the novel subfamily [1].
The profile we developed covers the entire RWD domain.
Last update:May 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Doerks T. Copley R.R. Schultz J. Ponting C.P. Bork P. |
| Title | Systematic identification of novel protein domain families associated with nuclear functions. | |
| Source | Genome Res. 12:47-56(2002). | |
| PubMed ID | 11779830 | |
| DOI | 10.1101/ |
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