PROSITE documentation PDOC50908
RWD domain profile


The RWD domain is a conserved region of about 110 amino acid residues, which has been identified in the mouse GCN2 eIF2α kinase and histidyl-tRNA synthetase and in presumed orthologs in other eukaryotic species from yeast to vertebrates. Additionally, it is also found in WD repeat containing proteins, yeast DEAD (DEXD)-like helicases, many RING-finger containing proteins, the UPF0029 uncharacterized protein family (see <PDOC00707>) and a range of hypothetical proteins. The RWD domain has been named after the better characterized RING finger (see <PDOC00449>) and WD repeat containing proteins (see <PDOC00574>) and DEAD-like helicaces (see <PDOC00039>). It has been proposed that the RWD domain might have a function in protein interaction [1].

The RWD domain is predicted to have an α/β secondary structure and is thought to be related to ubiquitin-conjugating enzymes (UBCc) domain, although the catalytic cysteine critical for ubiquitin-conjugating activity is not conserved in most members of the novel subfamily [1].

The profile we developed covers the entire RWD domain.

Last update:

May 2003 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RWD, PS50908; RWD domain profile  (MATRIX)


1AuthorsDoerks T. Copley R.R. Schultz J. Ponting C.P. Bork P.
TitleSystematic identification of novel protein domain families associated with nuclear functions.
SourceGenome Res. 12:47-56(2002).
PubMed ID11779830

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