PROSITE documentation PDOC51024
Zinc finger FCS-type profile


The FCS-type zinc finger, after the signature FCS residues associated with the third cysteine, is present in several polycomb group proteins. The FCS zinc finger is expected to adopt a Zn-ribbon like fold. Molecular data suggest that this domain can bind RNA in a non-sequence-specific manner [1].

Proteins known to contain an FCS-type zinc finger are listed below:

  • Drosphila polyhomeotic (ph) protein and vertebrate homologues. They are members of the Polycomb repressive complex 1 (PRC1), an inhibitory complex that acts by preventing chromatin remodeling and transcription.
  • Drosophila Sex comb on midleg (Scm) and vertebrate homologues. They are also members of the PRC1.
  • Drosphila Lethal(3) malignant brain tumor (l(3)mbt) protein and vertebrate homologues.

The profile we developed covers the entire FCS-type zinc finger.

Last update:

November 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_FCS, PS51024; Zinc finger FCS-type profile  (MATRIX)


1AuthorsZhang H. Christoforou A. Aravind L. Emmons S.W. van den Heuvel S. Haber D.A.
TitleThe C. elegans Polycomb Gene sop-2 Encodes an RNA Binding Protein.
SourceMol. Cell 14:841-847(2004).
PubMed ID15200961

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