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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE documentation PDOC51024
Zinc finger FCS-type profile


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PURL: https://purl.expasy.org/prosite/documentation/PDOC51024

Description

The FCS-type zinc finger, after the signature FCS residues associated with the third cysteine, is present in several polycomb group proteins. The FCS zinc finger is expected to adopt a Zn-ribbon like fold. Molecular data suggest that this domain can bind RNA in a non-sequence-specific manner [1].

Proteins known to contain an FCS-type zinc finger are listed below:

  • Drosphila polyhomeotic (ph) protein and vertebrate homologues. They are members of the Polycomb repressive complex 1 (PRC1), an inhibitory complex that acts by preventing chromatin remodeling and transcription.
  • Drosophila Sex comb on midleg (Scm) and vertebrate homologues. They are also members of the PRC1.
  • Drosphila Lethal(3) malignant brain tumor (l(3)mbt) protein and vertebrate homologues.

The profile we developed covers the entire FCS-type zinc finger.

Last update:

November 2004 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_FCS, PS51024; Zinc finger FCS-type profile  (MATRIX)


Reference

1AuthorsZhang H. Christoforou A. Aravind L. Emmons S.W. van den Heuvel S. Haber D.A.
TitleThe C. elegans Polycomb Gene sop-2 Encodes an RNA Binding Protein.
SourceMol. Cell 14:841-847(2004).
PubMed ID15200961
DOI10.1016/j.molcel.2004.06.001;



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