PROSITE entry PS51024
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General information about the entry
| Entry name [info] | ZF_FCS |
| Accession [info] | PS51024 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-2004 CREATED;
10-MAY-2017 DATA UPDATE; 03-MAY-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51024 |
| Associated ProRule [info] | PRU00367 |
Name and characterization of the entry
| Description [info] | Zinc finger FCS-type profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=36; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=33; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8880839; R2=0.0097104; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1506.6335449; R2=1.4524887; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=733; H_SCORE=2571; N_SCORE=9.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=475; H_SCORE=2197; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-9; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='P'; M= -8, -7,-29, -2, 12,-25,-16, -9,-24, 4,-26,-18, -5, 24, 3, 8, 3, -4,-23,-30,-21, 5; /M: SY='D'; M= 1, 9,-26, 12, -5,-26, 6,-14,-17,-12,-17,-14, 2,-14,-11,-18, -2,-10,-13,-27,-19, -9; /M: SY='P'; M=-11,-14,-32,-14, -6,-23,-10,-12,-11, -3,-15, -6, -8, 5, 4, 5, -9,-12,-15,-22,-15, -4; /M: SY='K'; M=-10, -9,-32, -7, -1,-28, -1,-12,-30, 17,-28,-15, -5, 10, -1, 16, -8,-12,-25,-22,-19, -3; /M: SY='S'; M= 14, 7,-14, 8, 1,-24, -2,-11,-21, -8,-25,-19, 7,-10, -2,-12, 26, 10,-11,-35,-20, -1; /M: SY='D'; M=-11, 17,-30, 26, 4,-34, 15, -9,-38, 5,-30,-22, 8,-13, -4, -4, -2,-13,-28,-28,-21, 0; /M: SY='M'; M=-12,-13,-24,-19, -9,-11,-20, -2, -2, 12, 0, 29,-11,-18, 4, 18,-16,-10, -3,-20, -4, -3; /M: SY='A'; M= 27,-18,-12,-24,-16,-10,-13,-22, 5,-16, 7, 0,-18,-18,-16,-20, -2, -2, 13,-22,-14,-16; /M: SY='T'; M= 8, -8,-14,-14, -9,-14,-18,-20, -7, 1,-11, -6, -8,-14, -9, -6, 6, 18, 5,-26,-12, -9; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='E'; M= -8, 6,-25, 9, 34,-25,-20, -7,-25, 12,-19,-16, 0, -4, 11, 3, 3, 4,-21,-28,-16, 23; /M: SY='W'; M=-16,-19,-33,-20,-10, -3,-22, -1,-11, -1, -9, 3,-17,-22, 7, 6,-19,-15,-18, 31, 20, -2; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='G'; M= -2,-14,-28,-14,-20,-22, 49,-20,-28,-22,-13,-12, -6,-22,-20,-20, -6,-18,-22,-20,-24,-20; /M: SY='E'; M= 1, 6,-23, 1, 12,-21,-12, -4,-16, 9,-16, -3, 7,-11, 5, 1, -1, -6,-16,-27,-15, 8; /M: SY='M'; M= -8,-23,-23,-29,-25, 9, -6,-19, 8,-22, 4, 13,-17,-24,-22,-20,-14,-11, 8,-15, -3,-23; /M: SY='G'; M= 6, -3,-26, -3, 6,-28, 15,-13,-29, 5,-24,-16, -2,-11, -2, -4, 0,-11,-21,-22,-21, 2; /M: SY='V'; M= -9,-22,-23,-20,-15, -8,-26, 2, 5,-18, 5, 4,-20, -3,-15,-16,-15, -9, 7,-28, -5,-17; /M: SY='K'; M= 1, -9,-28, -8, 2,-26,-16,-13,-23, 20,-24,-12, -7, 12, 1, 14, -6, -8,-18,-22,-17, -1; /M: SY='H'; M= 3, -1,-19, 0, -4,-16,-12, 7,-13,-13, -5, -6, -2,-17, -5,-13, 1, -3,-10,-29, -8, -5; /M: SY='Q'; M= 1, -2,-23, -5, 8,-29,-17, -4,-19, 12,-19, -6, -2,-10, 26, 6, 3, 2,-18,-22,-12, 17; /M: SY='F'; M=-18,-28,-22,-33,-25, 53,-30,-10, 4,-25, 16, 4,-22,-30,-29,-18,-22,-10, 0, 9, 36,-25; /I: I=-4; MI=0; MD=-22; IM=0; DM=-22; /M: SY='Y'; M= -9, -7,-17, -7, -2, 1,-15, 9, -5, -1, -5, 0, -7,-13, 11, -1, -7, -6,-11, 5, 25, 3; D=-4; /I: I=-4; DM=-22; /M: SY='T'; M= -3, -2,-12, -6, -4,-12,-13,-10,-14, 0,-13,-10, 2,-10, -2, 9, 13, 22, -6,-23,-10, -4; D=-4; /I: I=-4; DM=-22; /M: SY='K'; M=-10, -4,-30, -4, 1,-28, 2,-10,-32, 29,-28,-12, 0,-14, 3, 26, -8,-12,-22,-20,-15, 1; /M: SY='R'; M= -3, -2,-19, -4, 1,-21,-12,-10,-23, 13,-25,-14, 4,-12, 3, 16, 14, 11,-13,-29,-14, 1; /M: SY='K'; M=-12, -2,-30, -2, 8,-28,-20, -8,-30, 46,-28,-10, 0,-12, 10, 37,-10,-10,-20,-20,-10, 8; /M: SY='R'; M=-18, -5,-30, -3, 14,-22,-20, 0,-30, 25,-20,-12, 0,-15, 12, 53, -8,-10,-22,-22,-12, 10; /M: SY='F'; M=-20,-28,-22,-36,-28, 70,-30,-12, 0,-26, 8, 0,-20,-30,-34,-18,-20,-10, -2, 14, 40,-28; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='S'; M= 8, 0,-10, -2, -2,-18, -4,-12,-18,-10,-26,-18, 8,-10, -2,-10, 36, 26, -8,-38,-18, -2; /M: SY='M'; M= -8,-16,-27,-16, 0,-14,-26,-15, 7,-11, -2, 8,-17, 6, -6,-15,-11, -8, 3,-26,-13, -5; /M: SY='S'; M= 13, -4,-14, -8, -8,-20, 10,-16,-20,-12,-22,-16, 2,-12, -8,-14, 21, 15,-10,-30,-20, -8; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='S'; M= 12, -9,-15,-13, -9,-15,-10,-17, -1,-15,-14, -9, -1,-12, -7,-17, 20, 9, 1,-32,-15, -9; /M: SY='R'; M= -1, -8,-25,-10, 0,-22,-15, -7,-25, 25,-20,-10, -2,-16, 5, 40, -5, -8,-15,-20,-12, 0; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 21 in 21 different sequences |
| Number of true positive hits | 21 in 21 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 7 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 75.00 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | N_Hulo |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | ZN_FING |
| Feature description [info] | FCS-type |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
21 sequences
LMBL2_BOVIN (Q1JQD9 ), LMBL2_HUMAN (Q969R5 ), LMBL2_MOUSE (P59178 ), LMBL2_PONAB (Q5R737 ), LMBL2_RAT (Q3MIF2 ), MBTD1_HUMAN (Q05BQ5 ), MBTD1_MOUSE (Q6P5G3 ), MBTD1_XENLA (Q32N90 ), MBTD1_XENTR (Q6DIN3 ), PHC1_HUMAN (P78364 ), PHC1_MOUSE (Q64028 ), PHC2_DANRE (Q8QHL5 ), PHC2_HUMAN (Q8IXK0 ), PHC2_MOUSE (Q9QWH1 ), PHC2_XENLA (Q4V7W5 ), PHC3_HUMAN (Q8NDX5 ), PHC3_MOUSE (Q8CHP6 ), PHP_DROME (P39769 ), SCM_DROME (Q9VHA0 ), SMBT_DROME (Q9VK33 ), SMBT_DROPS (Q29L50 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
7 sequences
SOBPA_DANRE (A5X7A0 ), SOBPB_DANRE (A7XYJ6 ), SOBP_BOVIN (A7XYH9 ), SOBP_CHICK (A7XYH5 ), SOBP_HUMAN (A7XYQ1 ), SOBP_MOUSE (Q0P5V2 ), SOBP_RAT (A7XYI6 )» more |
| PDB [Detailed view] |
2 PDB
2L8E; 2W0T |