PROSITE documentation PDOC51053
SERTA domain profile


The SERTA (for SEI-1, RBT-1, and TARA) domain is a motif of ~47 residues corresponding to the largest conserved region among TRIP-Br (transcriptional regulator interacting with the PHD-bromodomain) proteins, an evolutionarily conserved family restricted to higher eukaryotes. In proteins of the TRIP-Br family, the SERTA domain is found in association with a cyclin A-binding domain and a PHD-bromo binding domain. The SERTA domain is also found in some other proteins with no conservation with TRIP-Br proteins outside of the SERTA motif. The cyclin-dependent kinase CDK4-interacting segment of TRIP-Br1 includes most of the SERTA domain [1,2].

Some proteins known to contain a SERTA domain are listed below:

  • Mammalian cell division cycle associated protein 4 (CDCA4) or hematopoietic progenitor protein (HEPP), a protein expressed preferentially in hematopoietic progenitors and mature blood cells.
  • Human TRIP-Br1/p34SEI-1, a cyclin-dependent kinase regulator interacting with PHD (see <PDOC50016>) and bromodomains (see <PDOC00550>), two modules widely found in chromosomal proteins.
  • Mammalian RBT1, a potent transcriptional coactivator that interacts with the second subunit of replication protein A.
  • Human Y127, an hypothetical 34-kD protein.
  • Drosophila TARANIS, a trithorax group (trxG) protein that might participate in a cell memory process coupling chromatin structure to cell cycle progression.
  • Drosophila CG2865.

The profile we developed covers the entire SERTA domain.

Last update:

January 2005 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SERTA, PS51053; SERTA domain profile  (MATRIX)


1AuthorsCalgaro S. Boube M. Cribbs D.L. Bourbon H.-M.
TitleThe Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus.
SourceGenetics 160:547-560(2002).
PubMed ID11861561

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