PROSITE documentation PDOC51053SERTA domain profile
The SERTA (for SEI-1, RBT-1, and TARA) domain is a motif of ~47 residues corresponding to the largest conserved region among TRIP-Br (transcriptional regulator interacting with the PHD-bromodomain) proteins, an evolutionarily conserved family restricted to higher eukaryotes. In proteins of the TRIP-Br family, the SERTA domain is found in association with a cyclin A-binding domain and a PHD-bromo binding domain. The SERTA domain is also found in some other proteins with no conservation with TRIP-Br proteins outside of the SERTA motif. The cyclin-dependent kinase CDK4-interacting segment of TRIP-Br1 includes most of the SERTA domain [1,2].
Some proteins known to contain a SERTA domain are listed below:
- Mammalian cell division cycle associated protein 4 (CDCA4) or hematopoietic progenitor protein (HEPP), a protein expressed preferentially in hematopoietic progenitors and mature blood cells.
- Human TRIP-Br1/p34SEI-1, a cyclin-dependent kinase regulator interacting with PHD (see <PDOC50016>) and bromodomains (see <PDOC00550>), two modules widely found in chromosomal proteins.
- Mammalian RBT1, a potent transcriptional coactivator that interacts with the second subunit of replication protein A.
- Human Y127, an hypothetical 34-kD protein.
- Drosophila TARANIS, a trithorax group (trxG) protein that might participate in a cell memory process coupling chromatin structure to cell cycle progression.
- Drosophila CG2865.
The profile we developed covers the entire SERTA domain.
Last update:January 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Calgaro S. Boube M. Cribbs D.L. Bourbon H.-M. |
Title | The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus. | |
Source | Genetics 160:547-560(2002). | |
PubMed ID | 11861561 |
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