PROSITE documentation PDOC51065Neuralized homology repeat (NHR) domain profile
The neuralized homology repeat (NHR) domain is a module of ~160 amino acids, which has been identified as a tandem repeat in drosophila neuralized, a protein involved in development of the central and peripheral nervous system [1]. Several other fly, worm, and mammalian neuralized-like proteins were found to contain between one and six NHR domains associated with other modules, such as RING (see <PDOC00449>), SOCS (see <PDOC50225>), or SPRY [2,3]. It has been suggested that the NHR domain is required for the localization of neuralized to the plasma membrane [4]. As it has been proposed that NHR domains do partly resemble SPRY domains, it is possible that NHR possess microtubule-binding functions, similar to those proposed for SPRY domains [3].
Some proteins known to contain a NHR domain are listed below:
- Drosophila neuralized protein. It is involved in neurogenesis and interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
- Mammalian neuralized-like protein 2. It plays an important role in the process of myofiber differentiation and maturation.
The profile we developed covers the entire NHR domain.
Note:The NHR domain has also been called NEUZ domain [2,3].
Last update:January 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Nakamura H. Yoshida M. Tsuiki H. Ito K. Ueno M. Nakao M. Oka K. Tada M. Kochi M. Kuratsu J. Ushio Y. Saya H. |
| Title | Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. | |
| Source | Oncogene 16:1009-1019(1998). | |
| PubMed ID | 9519875 | |
| DOI | 10.1038/sj.onc.1201618 |
| 2 | Authors | Doerks T. Copley R.R. Schultz J. Ponting C.P. Bork P. |
| Title | Systematic identification of novel protein domain families associated with nuclear functions. | |
| Source | Genome Res. 12:47-56(2002). | |
| PubMed ID | 11779830 |
| 3 | Authors | Ponting C.P. Mott R. Bork P. Copley R.R. |
| Title | Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. | |
| Source | Genome Res. 11:1996-2008(2001). | |
| PubMed ID | 11731489 | |
| DOI | 10.1101/gr.198701 |
| 4 | Authors | Yeh E. Dermer M. Commisso C. Zhou L. McGlade C.J. Boulianne G.L. |
| Title | Neuralized functions as an E3 ubiquitin ligase during Drosophila development. | |
| Source | Curr. Biol. 11:1675-1679(2001). | |
| PubMed ID | 11696324 |
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