PROSITE documentation PDOC51065
Neuralized homology repeat (NHR) domain profile


The neuralized homology repeat (NHR) domain is a module of ~160 amino acids, which has been identified as a tandem repeat in drosophila neuralized, a protein involved in development of the central and peripheral nervous system [1]. Several other fly, worm, and mammalian neuralized-like proteins were found to contain between one and six NHR domains associated with other modules, such as RING (see <PDOC00449>), SOCS (see <PDOC50225>), or SPRY [2,3]. It has been suggested that the NHR domain is required for the localization of neuralized to the plasma membrane [4]. As it has been proposed that NHR domains do partly resemble SPRY domains, it is possible that NHR possess microtubule-binding functions, similar to those proposed for SPRY domains [3].

Some proteins known to contain a NHR domain are listed below:

  • Drosophila neuralized protein. It is involved in neurogenesis and interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
  • Mammalian neuralized-like protein 2. It plays an important role in the process of myofiber differentiation and maturation.

The profile we developed covers the entire NHR domain.


The NHR domain has also been called NEUZ domain [2,3].

Last update:

January 2005 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NHR, PS51065; Neuralized homology repeat (NHR) domain profile  (MATRIX)


1AuthorsNakamura H. Yoshida M. Tsuiki H. Ito K. Ueno M. Nakao M. Oka K. Tada M. Kochi M. Kuratsu J. Ushio Y. Saya H.
TitleIdentification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region.
SourceOncogene 16:1009-1019(1998).
PubMed ID9519875

2AuthorsDoerks T. Copley R.R. Schultz J. Ponting C.P. Bork P.
TitleSystematic identification of novel protein domain families associated with nuclear functions.
SourceGenome Res. 12:47-56(2002).
PubMed ID11779830

3AuthorsPonting C.P. Mott R. Bork P. Copley R.R.
TitleNovel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution.
SourceGenome Res. 11:1996-2008(2001).
PubMed ID11731489

4AuthorsYeh E. Dermer M. Commisso C. Zhou L. McGlade C.J. Boulianne G.L.
TitleNeuralized functions as an E3 ubiquitin ligase during Drosophila development.
SourceCurr. Biol. 11:1675-1679(2001).
PubMed ID11696324

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)