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PROSITE documentation PDOC51082

WH2 domain profile





Description

The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain (see <PDOC50229>) and with the CRIB domain (see <PDOC50108>), and the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments [1,2,3,4].

Some proteins known to contain a WH2 domain:

  • Mammalian Wiskott-Aldrich syndrome protein (WASP), a possible regulator of lymphocyte and platelet function. Defects in WASP are the cause of Wiskott- Aldrich syndrome (WAS), an X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia. WASP proteins bind the actin nucleating protein complex Arp2/3.
  • Mammalian N-WASP/WASL and WASF/SCAR/WAVE1-3, and yeast LAS17, which are also proteins from the WASP family that participate in the transduction of signals from the cell surface to the actin cytoskeleton.
  • Baker's yeast Verprolin, a protein involved in cytoskeletal organization and cellular growth.
  • Human WASP interacting protein (WASPIP/WIP), a WASP-, profilin- and actin-binding protein which induces actin polymerization and redistribution.
  • Nuclear polyhedrosis virus (NPV) P61/78/83 capsid protein, which may be important for the persistence and survival of the virus.
  • Fruit fly Spir(e) protein, an actin nucleation factor involved in the development of oocytes and embryos. Spir is conserved among metazoans.
  • Mammalian metastasis suppressor 1 or Missing in Metastasis (MIM) protein, an actin-binding protein that may be related to cancer progression or tumor metastasis.

The profile we developed covers the entire WH2 domain.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

February 2005 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

WH2, PS51082; WH2 domain profile  (MATRIX)


References

1AuthorsMachesky L.M. Insall R.H. Volkman L.E.
TitleWASP homology sequences in baculoviruses.
SourceTrends Cell Biol. 11:286-287(2001).
PubMed ID11434350

2AuthorsEdwards J.
TitleAre beta-thymosins WH2 domains?
SourceFEBS Lett. 573:231-232(2004).
PubMed ID15328003
DOI10.1016/j.febslet.2004.07.038

3AuthorsPaunola E. Mattila P.K. Lappalainen P.
TitleWH2 domain: a small, versatile adapter for actin monomers.
SourceFEBS Lett. 513:92-97(2002).
PubMed ID11911886

4AuthorsQuinlan M.E. Heuser J.E. Kerkhoff E. Mullins R.D.
TitleDrosophila Spire is an actin nucleation factor.
SourceNature 433:382-388(2005).
PubMed ID15674283
DOI10.1038/nature03241



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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