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PROSITE documentation PDOC51082 |
The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain (see <PDOC50229>) and with the CRIB domain (see <PDOC50108>), and the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments [1,2,3,4].
Some proteins known to contain a WH2 domain:
The profile we developed covers the entire WH2 domain.
Last update:February 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Machesky L.M. Insall R.H. Volkman L.E. |
Title | WASP homology sequences in baculoviruses. | |
Source | Trends Cell Biol. 11:286-287(2001). | |
PubMed ID | 11434350 |
2 | Authors | Edwards J. |
Title | Are beta-thymosins WH2 domains? | |
Source | FEBS Lett. 573:231-232(2004). | |
PubMed ID | 15328003 | |
DOI | 10.1016/j.febslet.2004.07.038 |
3 | Authors | Paunola E. Mattila P.K. Lappalainen P. |
Title | WH2 domain: a small, versatile adapter for actin monomers. | |
Source | FEBS Lett. 513:92-97(2002). | |
PubMed ID | 11911886 |
4 | Authors | Quinlan M.E. Heuser J.E. Kerkhoff E. Mullins R.D. |
Title | Drosophila Spire is an actin nucleation factor. | |
Source | Nature 433:382-388(2005). | |
PubMed ID | 15674283 | |
DOI | 10.1038/nature03241 |