PROSITE entry PS51082
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General information about the entry
| Entry name [info] | WH2 |
| Accession [info] | PS51082 |
| Entry type [info] | MATRIX |
| Date [info] |
01-FEB-2005 CREATED;
01-OCT-2013 DATA UPDATE; 03-MAY-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51082 |
| Associated ProRule [info] | PRU00406 |
Name and characterization of the entry
| Description [info] | WH2 domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=20; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.1699438; R2=0.0172713; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=141; N_SCORE=7.6; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=43; N_SCORE=5.9; MODE=1; TEXT='RR'; /DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*; ... A C D E F G H I K L M N P Q R S T V W Y /I: B0=-85; B1=-85; BM=-1; BD=-44; /M: SY='D'; M= 12,-32, 14, -3,-36, 12,-14,-33,-10,-14, 7, 5, 6, 3,-15, 4, -6,-29,-34,-28; M0=-7; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='R'; M=-22,-36,-20, -3,-40, 1, 14,-37, -3,-36,-27, -1, -9,-13, 35,-21, -7,-33,-37,-31; M0=-16; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='S'; M= 8,-34, 14, -1,-38, 2,-16,-35,-12,-35,-25, 15,-30, 8,-17, 19, -4,-31,-36,-29; M0=-11; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 22,-33, 11, 11,-36,-28,-14,-33,-10,-12,-24, 5, 5, 8,-15,-17, -6,-13,-34,-28; M0=-9; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-49,-43,-72,-66, 0,-69,-55,-20,-64, 31, 10,-66,-61, 9,-59,-62,-47, -8,-42,-44; M0=-39; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-52,-46,-76,-70, 5,-75,-59,-20,-68, 30, 28,-72,-63,-54,-62,-69,-51,-29,-43,-45; M0=-45; /I: MM=-1; MI=-95; MD=-48; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 18,-32, 12, 14,-36, 3,-14,-33, 0,-12,-23, 1,-28, 1,-15, 4,-17,-29,-34,-27; M0=-9; /I: MM=0; MI=-94; MD=-105; IM=-9; II=-11; DM=-4; DD=-20; /M: SY='Q'; M= 17,-43, 12, 17,-46, 0,-22,-44,-20,-43,-34,-19,-36, 24,-26, -1,-27,-39,-45,-37; M0=-17; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='I'; M=-59,-52,-69,-72,-56,-61,-65, 41,-72,-48,-48,-69,-64,-70,-68,-69,-60,-35,-60,-62; M0=-55; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='R'; M=-31, 7,-33, -5,-48,-39, 19,-44, 16,-11,-34,-26,-39, 16, 31,-30,-30,-40,-41,-38; M0=-21; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= 8,-33,-16, 3,-36, 2,-14,-33, 13,-33, -1, 7,-29, 24, 4, 4, -6,-29,-34,-28; M0=-10; /I: MM=-46; MI=-21; MD=-4; IM=0; II=-52; DM=-7; DD=-14; /M: SY='G'; M= -8,-22, 12, 0,-26, 17, -4,-23, 11,-23,-14, -3,-18, 0, -6, 5, 8,-19,-25,-18; M0=-6; /I: MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48; /M: SY='G'; M=-31,-39,-27,-30,-59, 35,-37,-57, 4,-57,-50, -2,-43,-34,-37,-11,-34,-48,-58,-53; M0=-31; /I: MM=-24; MI=-38; MD=-4; IM=-1; II=-36; DM=-7; DD=-14; /M: SY='I'; M= 5,-11,-13, -7,-11,-19, -6, 16, 9, 1, -2, -9,-20, -4, 9, -9, 7, -5,-14,-10; M0=-3; /I: MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48; /M: SY='I'; M= 3, 7, -8,-35, 12,-13,-24, 14, 14, -9, 14,-31, 5,-28,-30,-26, 6, 6,-23,-20; M0=-8; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= -8,-33, -3, -2,-36,-28,-14,-33, 22,-33,-24,-14,-29, 24, 14, 5, 0,-29,-35,-28; M0=-13; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-64,-56,-72,-73,-43,-63,-64,-40,-73, 34,-32,-73,-65,-66,-68,-74,-64,-48,-54,-58; M0=-53; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='K'; M=-44,-50,-56,-38,-60,-49,-26,-52, 32,-14,-41, -9,-48,-22, 27,-43,-40,-50,-45,-45; M0=-32; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='K'; M=-40,-48,-45,-33,-56,-46, 17,-50, 33,-46,-39,-32, 19,-21, 0, -5,-37,-47,-45,-43; M0=-28; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='V'; M= 6,-23,-50,-44,-25,-42,-33, 2,-40,-11,-16,-39,-43,-37,-39, -9, 21, 27,-31,-28; M0=-20; /I: E0=-10; E1=-10;» more |
Numerical results [info]
| Total number of hits | 125 in 100 different sequences |
| Number of true positive hits | 125 in 100 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 30 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 80.65 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | PS_Langendijk_Genevaux |
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
| Maximum number of repetitions [info] | 3 |
| Feature key [info] | DOMAIN |
| Feature description [info] | WH2 |
| Version [info] | 4 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
100 sequences
ACTOA_DICDI (Q55DU3 ), ACTOB_DICDI (Q55DU1 ), ACTO_ENTHI (O15602 ), COBL1_HUMAN (Q53SF7 ), COBL_DANRE (E7F568 ), COBL_HUMAN (O75128 ), COBL_MOUSE (Q5NBX1 ), COBL_RAT (D3ZUI5 ), ESPN_HUMAN (B1AK53 ), ESPN_MOUSE (Q9ET47 ), ESPN_RAT (Q63618 ), INF2_HUMAN (Q27J81 ), INF2_MOUSE (Q0GNC1 ), INF2_XENLA (Q6NTV6 ), INF2_XENTR (Q0IHV1 ), JMY_DANRE (Q6NVC9 ), JMY_HUMAN (Q8N9B5 ), JMY_MOUSE (Q9QXM1 ), JMY_XENTR (A8E4X8 ), LAS17_YEAST (Q12446 ), LMOD1_HUMAN (P29536 ), LMOD1_MOUSE (Q8BVA4 ), LMOD1_RAT (A0A0G2K0D3), LMOD2_CHICK (E1BTG2 ), LMOD2_HUMAN (Q6P5Q4 ), MTSS1_HUMAN (O43312 ), MTSS1_MOUSE (Q8R1S4 ), P78_NPVAC (Q03209 ), PAN1_AJECN (A6R7X5 ), PAN1_ASPCL (A1CD74 ), PAN1_ASPFC (B0YC95 ), PAN1_ASPFU (Q4WG58 ), PAN1_ASPNC (A2R180 ), PAN1_ASPOR (Q2UDY8 ), PAN1_ASPTN (Q0CPW4 ), PAN1_CANAL (Q5AHB1 ), PAN1_CHAGB (Q2H922 ), PAN1_COCIM (Q1DQC1 ), PAN1_DEBHA (Q6BNL1 ), PAN1_EMENI (Q5B5B0 ), PAN1_LODEL (A5DVD6 ), PAN1_NEOFI (A1DC51 ), PAN1_PICGU (A5DP36 ), PAN1_PICST (A3LN86 ), PAN1_SCHPO (Q10172 ), PXK_HUMAN (Q7Z7A4 ), PXK_MOUSE (Q8BX57 ), PXK_RAT (Q4FZZ1 ), RICKA_RICBR (Q1RI78 ), RICKA_RICFE (Q4UMI6 ), RICKA_RICMO (Q9AKP3 ), SCAR2_ARATH (Q5XPJ9 ), SCAR_DICDI (Q54NF8 ), SCRL1_ORYSJ (Q84TX2 ), SCRL2_ORYSJ (Q5QNA6 ), SLOB1_DICDI (Q54TC3 ), SPIR2_DANRE (Q5U3H9 ), SPIR2_HUMAN (Q8WWL2 ), SPIR2_MOUSE (Q8K1S6 ), SPIR_DROME (Q9U1K1 ), SPIR_DROPS (Q29KT5 ), VASP_DICDI (Q5TJ65 ), VP61_NPVOP (O10270 ), VRP1_SCHPO (Q9P6R1 ), VRP1_YEAST (P37370 ), WASF1_BOVIN (Q0IIJ3 ), WASF1_HUMAN (Q92558 ), WASF1_MOUSE (Q8R5H6 ), WASF1_PONAB (Q5NVG8 ), WASF1_RAT (Q5BJU7 ), WASF2_BOVIN (A2VDK6 ), WASF2_HUMAN (Q9Y6W5 ), WASF2_MOUSE (Q8BH43 ), WASF3_HUMAN (Q9UPY6 ), WASF3_MOUSE (Q8VHI6 ), WASH1_BOVIN (A7Z063 ), WASH1_CHICK (Q5ZKA6 ), WASH1_DICDI (Q54CK9 ), WASH1_MOUSE (Q8VDD8 ), WASH1_RAT (B2RYF7 ), WASH1_XENTR (Q28DN4 ), WASH2_HUMAN (Q6VEQ5 ), WASH3_HUMAN (C4AMC7 ), WASL_BOVIN (Q95107 ), WASL_HUMAN (O00401 ), WASL_MOUSE (Q91YD9 ), WASL_RAT (O08816 ), WASP_HUMAN (P42768 ), WASP_MOUSE (P70315 ), WHAMM_HUMAN (Q8TF30 ), WHAMM_MOUSE (Q571B6 ), WIPF1_HUMAN (O43516 ), WIPF1_MOUSE (Q8K1I7 ), WIPF1_RAT (Q6IN36 ), WIPF2_HUMAN (Q8TF74 ), WIPF2_MOUSE (Q6PEV3 ), WIPF3_HUMAN (A6NGB9 ), WIPF3_MOUSE (P0C7L0 ), WIPF3_RAT (Q9Z0G8 ), WSP1_SCHPO (O36027 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
30 sequences
ACTO_ACACA (P18281 ), COBL1_MOUSE (Q3UMF0 ), LMOD2_MOUSE (Q3UHZ5 ), LMOD2_RAT (A1A5Q0 ), LMOD3_DANRE (E7F7X0 ), LMOD3_HUMAN (Q0VAK6 ), LMOD3_MOUSE (E9QA62 ), MTSS2_HUMAN (Q765P7 ), MTSS2_MOUSE (Q6P9S0 ), PAN1_BOTFB (A6S9N4 ), PAN1_MAGO7 (A4R8N4 ), PAN1_NEUCR (Q7SAT8 ), PAN1_SCLS1 (A7EKZ0 ), PAN1_YARLI (Q6C908 ), RICKA_RICCN (Q92H62 ), RICKA_RICRI (Q9AKJ0 ), SCAR1_ARATH (Q6AWX6 ), SCAR3_ARATH (Q9LP46 ), SCAR4_ARATH (Q5XPJ6 ), SPIR1_DANRE (Q1LYM3 ), SPIR1_HUMAN (Q08AE8 ), SPIR1_MACFA (Q4R707 ), SPIR1_MOUSE (Q52KF3 ), WASH1_CAEEL (O18195 ), WASH1_DANRE (A4IG59 ), WASH1_DROME (Q7JW27 ), WASH1_HUMAN (A8K0Z3 ), WASH1_XENLA (Q5U4A3 ), WASH4_HUMAN (A8MWX3 ), WASH6_HUMAN (Q9NQA3 )» more |
| PDB [Detailed view] |
25 PDB
2A3Z; 2A40; 2A41; 2D1K; 2VCP; 3M3N; 3MN5; 3MN7; 3P8C; 3TU5; 3UE5; 4EFH; 4JHD; 4N78; 4RWT; 5WFN; 5YPU; 6JBK; 6JCU; 6JH8; 6JH9; 6UHC; 7USC; 7USD; 7USE » more |