PROSITE entry PS51082
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS51082 |
| Entry name [info] | WH2 |
| Accession [info] | PS51082 |
| Entry type [info] | MATRIX |
| Date [info] |
01-FEB-2005 CREATED;
01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51082 |
| Associated ProRule [info] | PRU00406 |
Name and characterization of the entry
| Description [info] | WH2 domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=20; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.1699438; R2=0.0172713; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=141; N_SCORE=7.6; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=43; N_SCORE=5.9; MODE=1; TEXT='RR'; /DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*; ... A C D E F G H I K L M N P Q R S T V W Y /I: B0=-85; B1=-85; BM=-1; BD=-44; /M: SY='D'; M= 12,-32, 14, -3,-36, 12,-14,-33,-10,-14, 7, 5, 6, 3,-15, 4, -6,-29,-34,-28; M0=-7; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='R'; M=-22,-36,-20, -3,-40, 1, 14,-37, -3,-36,-27, -1, -9,-13, 35,-21, -7,-33,-37,-31; M0=-16; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='S'; M= 8,-34, 14, -1,-38, 2,-16,-35,-12,-35,-25, 15,-30, 8,-17, 19, -4,-31,-36,-29; M0=-11; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 22,-33, 11, 11,-36,-28,-14,-33,-10,-12,-24, 5, 5, 8,-15,-17, -6,-13,-34,-28; M0=-9; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-49,-43,-72,-66, 0,-69,-55,-20,-64, 31, 10,-66,-61, 9,-59,-62,-47, -8,-42,-44; M0=-39; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-52,-46,-76,-70, 5,-75,-59,-20,-68, 30, 28,-72,-63,-54,-62,-69,-51,-29,-43,-45; M0=-45; /I: MM=-1; MI=-95; MD=-48; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 18,-32, 12, 14,-36, 3,-14,-33, 0,-12,-23, 1,-28, 1,-15, 4,-17,-29,-34,-27; M0=-9; /I: MM=0; MI=-94; MD=-105; IM=-9; II=-11; DM=-4; DD=-20; /M: SY='Q'; M= 17,-43, 12, 17,-46, 0,-22,-44,-20,-43,-34,-19,-36, 24,-26, -1,-27,-39,-45,-37; M0=-17; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='I'; M=-59,-52,-69,-72,-56,-61,-65, 41,-72,-48,-48,-69,-64,-70,-68,-69,-60,-35,-60,-62; M0=-55; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='R'; M=-31, 7,-33, -5,-48,-39, 19,-44, 16,-11,-34,-26,-39, 16, 31,-30,-30,-40,-41,-38; M0=-21; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= 8,-33,-16, 3,-36, 2,-14,-33, 13,-33, -1, 7,-29, 24, 4, 4, -6,-29,-34,-28; M0=-10; /I: MM=-46; MI=-21; MD=-4; IM=0; II=-52; DM=-7; DD=-14; /M: SY='G'; M= -8,-22, 12, 0,-26, 17, -4,-23, 11,-23,-14, -3,-18, 0, -6, 5, 8,-19,-25,-18; M0=-6; /I: MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48; /M: SY='G'; M=-31,-39,-27,-30,-59, 35,-37,-57, 4,-57,-50, -2,-43,-34,-37,-11,-34,-48,-58,-53; M0=-31; /I: MM=-24; MI=-38; MD=-4; IM=-1; II=-36; DM=-7; DD=-14; /M: SY='I'; M= 5,-11,-13, -7,-11,-19, -6, 16, 9, 1, -2, -9,-20, -4, 9, -9, 7, -5,-14,-10; M0=-3; /I: MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48; /M: SY='I'; M= 3, 7, -8,-35, 12,-13,-24, 14, 14, -9, 14,-31, 5,-28,-30,-26, 6, 6,-23,-20; M0=-8; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= -8,-33, -3, -2,-36,-28,-14,-33, 22,-33,-24,-14,-29, 24, 14, 5, 0,-29,-35,-28; M0=-13; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='L'; M=-64,-56,-72,-73,-43,-63,-64,-40,-73, 34,-32,-73,-65,-66,-68,-74,-64,-48,-54,-58; M0=-53; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='K'; M=-44,-50,-56,-38,-60,-49,-26,-52, 32,-14,-41, -9,-48,-22, 27,-43,-40,-50,-45,-45; M0=-32; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='K'; M=-40,-48,-45,-33,-56,-46, 17,-50, 33,-46,-39,-32, 19,-21, 0, -5,-37,-47,-45,-43; M0=-28; /I: MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='V'; M= 6,-23,-50,-44,-25,-42,-33, 2,-40,-11,-16,-39,-43,-37,-39, -9, 21, 27,-31,-28; M0=-20; /I: E0=-10; E1=-10;» more |
Numerical results [info]
| Total number of hits | 126 in 101 different sequences |
| Number of true positive hits | 126 in 101 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 30 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 80.77 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
| Maximum number of repetitions [info] | 3 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | PS_Langendijk_Genevaux |
| Feature key [info] | DOMAIN |
| Feature description [info] | WH2 |
| Version [info] | 4 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
101 sequences
ACTOA_DICDI (Q55DU3), ACTOB_DICDI (Q55DU1), ACTO_ENTHI (O15602), BIMA_BURTA (Q2T6X7), COBL1_HUMAN (Q53SF7), COBL_DANRE (E7F568), COBL_HUMAN (O75128), COBL_MOUSE (Q5NBX1), COBL_RAT(D3ZUI5), ESPN_HUMAN (B1AK53), ESPN_MOUSE (Q9ET47), ESPN_RAT(Q63618), INF2_HUMAN (Q27J81), INF2_MOUSE (Q0GNC1), INF2_XENLA (Q6NTV6), INF2_XENTR (Q0IHV1), JMY_DANRE (Q6NVC9), JMY_HUMAN (Q8N9B5), JMY_MOUSE (Q9QXM1), JMY_XENTR (A8E4X8), LAS17_YEAST (Q12446), LMOD1_HUMAN (P29536), LMOD1_MOUSE (Q8BVA4), LMOD1_RAT (A0A0G2K0D3), LMOD2_CHICK (E1BTG2), LMOD2_HUMAN (Q6P5Q4), MTSS1_HUMAN (O43312), MTSS1_MOUSE (Q8R1S4), P78_NPVAC (Q03209), PAN1_AJECN (A6R7X5), PAN1_ASPCL (A1CD74), PAN1_ASPFC (B0YC95), PAN1_ASPFU (Q4WG58), PAN1_ASPNC (A2R180), PAN1_ASPOR (Q2UDY8), PAN1_ASPTN (Q0CPW4), PAN1_CANAL (Q5AHB1), PAN1_CHAGB (Q2H922), PAN1_COCIM (Q1DQC1), PAN1_DEBHA (Q6BNL1), PAN1_EMENI (Q5B5B0), PAN1_LODEL (A5DVD6), PAN1_NEOFI (A1DC51), PAN1_PICGU (A5DP36), PAN1_PICST (A3LN86), PAN1_SCHPO (Q10172), PXK_HUMAN (Q7Z7A4), PXK_MOUSE (Q8BX57), PXK_RAT (Q4FZZ1), RICKA_RICBR (Q1RI78), RICKA_RICFE (Q4UMI6), RICKA_RICMO (Q9AKP3), SCAR2_ARATH (Q5XPJ9), SCAR_DICDI (Q54NF8), SCRL1_ORYSJ (Q84TX2), SCRL2_ORYSJ (Q5QNA6), SLOB1_DICDI (Q54TC3), SPIR2_DANRE (Q5U3H9), SPIR2_HUMAN (Q8WWL2), SPIR2_MOUSE (Q8K1S6), SPIR_DROME (Q9U1K1), SPIR_DROPS (Q29KT5), VASP_DICDI (Q5TJ65), VP61_NPVOP (O10270), VRP1_SCHPO (Q9P6R1), VRP1_YEAST (P37370), WASF1_BOVIN (Q0IIJ3), WASF1_HUMAN (Q92558), WASF1_MOUSE (Q8R5H6), WASF1_PONAB (Q5NVG8), WASF1_RAT (Q5BJU7), WASF2_BOVIN (A2VDK6), WASF2_HUMAN (Q9Y6W5), WASF2_MOUSE (Q8BH43), WASF3_HUMAN (Q9UPY6), WASF3_MOUSE (Q8VHI6), WASH1_BOVIN (A7Z063), WASH1_CHICK (Q5ZKA6), WASH1_DICDI (Q54CK9), WASH1_MOUSE (Q8VDD8), WASH1_RAT (B2RYF7), WASH1_XENTR (Q28DN4), WASH2_HUMAN (Q6VEQ5), WASH3_HUMAN (C4AMC7), WASL_BOVIN (Q95107), WASL_HUMAN (O00401), WASL_MOUSE (Q91YD9), WASL_RAT(O08816), WASP_HUMAN (P42768), WASP_MOUSE (P70315), WHAMM_HUMAN (Q8TF30), WHAMM_MOUSE (Q571B6), WIPF1_HUMAN (O43516), WIPF1_MOUSE (Q8K1I7), WIPF1_RAT (Q6IN36), WIPF2_HUMAN (Q8TF74), WIPF2_MOUSE (Q6PEV3), WIPF3_HUMAN (A6NGB9), WIPF3_MOUSE (P0C7L0), WIPF3_RAT (Q9Z0G8), WSP1_SCHPO (O36027)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
30 sequences
ACTO_ACACA (P18281), COBL1_MOUSE (Q3UMF0), LMOD2_MOUSE (Q3UHZ5), LMOD2_RAT (A1A5Q0), LMOD3_DANRE (E7F7X0), LMOD3_HUMAN (Q0VAK6), LMOD3_MOUSE (E9QA62), MTSS2_HUMAN (Q765P7), MTSS2_MOUSE (Q6P9S0), PAN1_BOTFB (A6S9N4), PAN1_NEUCR (Q7SAT8), PAN1_PYRO7 (A4R8N4), PAN1_SCLS1 (A7EKZ0), PAN1_YARLI (Q6C908), RICKA_RICCN (Q92H62), RICKA_RICRI (Q9AKJ0), SCAR1_ARATH (Q6AWX6), SCAR3_ARATH (Q9LP46), SCAR4_ARATH (Q5XPJ6), SPIR1_DANRE (Q1LYM3), SPIR1_HUMAN (Q08AE8), SPIR1_MACFA (Q4R707), SPIR1_MOUSE (Q52KF3), WASH1_CAEEL (O18195), WASH1_DANRE (A4IG59), WASH1_DROME (Q7JW27), WASH1_HUMAN (A8K0Z3), WASH1_XENLA (Q5U4A3), WASH4_HUMAN (A8MWX3), WASH6_HUMAN (Q9NQA3)» more |
| PDB [Detailed view] |
27 PDB
2A3Z; 2A40; 2A41; 2D1K; 2VCP; 3M3N; 3MN5; 3MN7; 3P8C; 3TU5; 3UE5; 4EFH; 4JHD; 4N78; 4RWT; 5WFN; 5YPU; 6JBK; 6JCU; 6JH8; 6JH9; 6UHC; 7USC; 7USD; 7USE; 8RV2; 9AZP » more |