PROSITE documentation PDOC51087ApaG domain profile
The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain (see <PDOC50181>). The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several β-sheets (see <PDB:1XVS>). The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity [1,2,3,4].
Some proteins known to contain an apaG domain:
- Escherichia coli apaG, a protein that is well-conserved among diverse bacteria.
- Salmonella typhimurium apaG/corD, involved in Co(2+) sensitivity and Mg(2+) homeostasis [1].
- Mammalian FBA/F-box only protein 3, a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex [2].
- Mammalian PDIP38/POLD2-interacting protein, which interacts with proliferating cell nuclear antigen (PCNA) and the p50 subunit of DNA polymerase delta. It is conserved among metazoans [3].
The profile we developed covers the entire apaG domain.
Last update:March 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Gibson M.M. Bagga D.A. Miller C.G. Maguire M.E. |
| Title | Magnesium transport in Salmonella typhimurium: the influence of new mutations conferring Co2+ resistance on the CorA Mg2+ transport system. | |
| Source | Mol. Microbiol. 5:2753-2762(1991). | |
| PubMed ID | 1779764 |
| 2 | Authors | Ilyin G.P. Rialland M. Pigeon C. Guguen-Guillouzo C. |
| Title | cDNA cloning and expression analysis of new members of the mammalian F-box protein family. | |
| Source | Genomics 67:40-47(2000). | |
| PubMed ID | 10945468 |
| 3 | Authors | Liu L. Rodriguez-Belmonte E.M. Mazloum N. Xie B. Lee M.Y.W.T. |
| Title | Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. | |
| Source | J. Biol. Chem. 278:10041-10047(2003). | |
| PubMed ID | 12522211 | |
| DOI | 10.1074/jbc.M208694200 |
| 4 | Authors | Katsuyama A.M. Cicero D.O. Spisni A. Paci M. Farah C.S. Pertinhez T.A. |
| Title | 1H, 15N and 13C resonance assignments of the ApaG protein of the phytopathogen Xanthomonas axonopodis pv. citri. | |
| Source | J. Biomol. NMR 29:423-424(2004). | |
| PubMed ID | 15213450 | |
| DOI | 10.1023/B:JNMR.0000032502.66997.25 |
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