PROSITE documentation PDOC51111
REJ domain profile


The REJ domain is an extracellular module of ~700 amino acids, which is found associated with others domains, such as EGF (see <PDOC00021>), the GPS proteolytic cleavage site (see <PDOC50221>), C-type lectin (see <PDOC00537>), SUEL-type lectin (see <PDOC50228>), LRR, LDL-A, PLAT (see <PDOC50095>) or PKD (see <PDOC50093>) [1,2]. Although its function is unknown, the REJ domain has been shown to be required for cleavage to occur at the GPS [3]. It has been proposed that the REJ domain might function in ion transport homeostasis [1].

Some proteins known to contain a REJ domain are listed below:

  • Sea urchin sperm receptor for egg jelly 1 (suREJ1). It binds to the fucose sulfate polymer of egg jelly to induce the sperm acrosome reaction [4].
  • Sea urchin sperm receptor for egg jelly 2 (suREJ2). It is present over the entire sperm plasma membrane, but is concentrated over the sperm mitochondrion [4].
  • Sea urchin sperm receptor for egg jelly 3 (suREJ3). It localizes over the acrosomal vesicle [4].
  • Human autosomal dominant polycystic kidney disease protein polycystin-1. It is thought to be part of a plasma membrane signaling/ion channel complex involved in maintaining the terminally differentiated state of renal tubular epithelial cells.
  • Mammalian polycystic kidney disease and receptor for egg jelly related protein (PKDREJ), a testis-specific protein whose function is unknown [5].
  • Mammalian polycystic kidney disease 1-like 1 protein (PKD1L1),

The profile we developed covers the entire REJ domain.

Last update:

November 2005 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

REJ, PS51111; REJ domain profile  (MATRIX)


1AuthorsMoy G.W. Mendoza L.M. Schulz J.R. Swanson W.J. Glabe C.G. Vacquier V.D.
TitleThe sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1.
SourceJ. Cell Biol. 133:809-817(1996).
PubMed ID8666666

2AuthorsSandford R. Sgotto B. Aparicio S. Brenner S. Vaudin M. Wilson R.K. Chissoe S. Pepin K. Bateman A. Chothia C. Hughes J. Harris P.
TitleComparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains.
SourceHum. Mol. Genet. 6:1483-1489(1997).
PubMed ID9285785

3AuthorsQian F. Boletta A. Bhunia A.K. Xu H. Liu L. Ahrabi A.K. Watnick T.J. Zhou F. Germino G.G.
TitleCleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.
SourceProc. Natl. Acad. Sci. U.S.A. 99:16981-16986(2002).
PubMed ID12482949

4AuthorsGalindo B.E. Moy G.W. Vacquier V.D.
TitleA third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion.
SourceDev. Growth Differ. 46:53-60(2004).
PubMed ID15008854

5AuthorsHughes J. Ward C.J. Aspinwall R. Butler R. Harris P.C.
TitleIdentification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein.
SourceHum. Mol. Genet. 8:543-549(1999).
PubMed ID9949214

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