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PROSITE documentation PDOC51111 |
The REJ domain is an extracellular module of ~700 amino acids, which is found associated with others domains, such as EGF (see <PDOC00021>), the GPS proteolytic cleavage site (see <PDOC50221>), C-type lectin (see <PDOC00537>), SUEL-type lectin (see <PDOC50228>), LRR, LDL-A, PLAT (see <PDOC50095>) or PKD (see <PDOC50093>) [1,2]. Although its function is unknown, the REJ domain has been shown to be required for cleavage to occur at the GPS [3]. It has been proposed that the REJ domain might function in ion transport homeostasis [1].
Some proteins known to contain a REJ domain are listed below:
The profile we developed covers the entire REJ domain.
Last update:November 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Moy G.W. Mendoza L.M. Schulz J.R. Swanson W.J. Glabe C.G. Vacquier V.D. |
Title | The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1. | |
Source | J. Cell Biol. 133:809-817(1996). | |
PubMed ID | 8666666 |
2 | Authors | Sandford R. Sgotto B. Aparicio S. Brenner S. Vaudin M. Wilson R.K. Chissoe S. Pepin K. Bateman A. Chothia C. Hughes J. Harris P. |
Title | Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. | |
Source | Hum. Mol. Genet. 6:1483-1489(1997). | |
PubMed ID | 9285785 |
3 | Authors | Qian F. Boletta A. Bhunia A.K. Xu H. Liu L. Ahrabi A.K. Watnick T.J. Zhou F. Germino G.G. |
Title | Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 99:16981-16986(2002). | |
PubMed ID | 12482949 | |
DOI | 10.1073/pnas.252484899 |
4 | Authors | Galindo B.E. Moy G.W. Vacquier V.D. |
Title | A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion. | |
Source | Dev. Growth Differ. 46:53-60(2004). | |
PubMed ID | 15008854 |
5 | Authors | Hughes J. Ward C.J. Aspinwall R. Butler R. Harris P.C. |
Title | Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. | |
Source | Hum. Mol. Genet. 8:543-549(1999). | |
PubMed ID | 9949214 |