PROSITE documentation PDOC51126Dilute domain profile
The myosin superfamily consists of at least 15 distinct classes of presumed actin-based molecular motors. All members of the superfamily share a similar motor domain and a tail portion which is diagnostic of the class [1].
Class V myosins are actin-based molecular motors that function in relatively long-range movements of many intracellular cargoes including organelles, membrane vesicles, and mRNA [2]. These motors are ubiquitously found in all eukaryotes. Class V myosins are characterised by the presence of a conserved globular domain at the C-terminus of the tail portion: the dilute domain [3]. Myosin V moves via attachment of its amino terminal head (motor) domain to actin cables; its carboxyl terminal dilute domain anchors it to cargoes via attachments to organelle-specific receptors [2,4].
The dilute domain is also found in the afadin family. Afadins are nectin and actin filament-binding proteins that connect nectin to the actin cytoskeleton [5].
The profile we developed covers the whole dilute domain.
Last update:June 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Oliver T.N. Berg J.S. Cheney R.E. |
| Title | Tails of unconventional myosins. | |
| Source | Cell. Mol. Life Sci. 56:243-257(1999). | |
| PubMed ID | 11212352 |
| 2 | Authors | Catlett N.L. Duex J.E. Tang F. Weisman L.S. |
| Title | Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes. | |
| Source | J. Cell Biol. 150:513-526(2000). | |
| PubMed ID | 10931864 |
| 3 | Authors | Ponting C.P. |
| Title | AF-6/cno: neither a kinesin nor a myosin, but a bit of both. | |
| Source | Trends Biochem. Sci. 20:265-266(1995). | |
| PubMed ID | 7667878 |
| 4 | Authors | Pashkova N. Catlett N.L. Novak J.L. Wu G. Lu R. Cohen R.E. Weisman L.S. |
| Title | Myosin V attachment to cargo requires the tight association of two functional subdomains. | |
| Source | J. Cell Biol. 168:359-364(2005). | |
| PubMed ID | 15684027 | |
| DOI | 10.1083/jcb.200407146 |
| 5 | Authors | Takai Y. Nakanishi H. |
| Title | Nectin and afadin: novel organizers of intercellular junctions. | |
| Source | J. Cell Sci. 116:17-27(2003). | |
| PubMed ID | 12456712 |
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