PROSITE documentation PDOC51153
RPW8 domain profile


Plant diseases resistance (R) proteins control the recognition of specific pathogens and activate subsequent defense responses. The R protein-mediated defenses typically involve a rapid, localized necrosis, or hypersensitive response (HR), at the site of infection, and the localized formation of antimicrobial chemicals and proteins that restrict growth of the pathogen. The Arabidopsis proteins RPW8.1 and RPW8.2 confer broad-spectrum resistance to powdery mildew pathogens. They share similarity with an ~150 amino acid module forming the N-terminus of a group of disease resistance proteins, which have a nucleotide-binding site (NBS) and leucine-rich repeats (LRRs) [1,2].

The RPW8 domain sequences predicted an N-terminal transmembrane (TM) region, or possibly a signal peptide, and a coiled-coil (CC) motif [1].

Some proteins known to contain a RPW8 domain are listed below:

  • Arabidopsis thaliana RPW8.1 and RPW8.2.
  • Arabidopsis thaliana Homologous to RPW8 1 (HR1), 2 (HR2) and 3 (HR3).
  • Arabidopsis thaliana activated disease resistance protein 1 (ADR1).
  • Brassica HRa, HRb and Hrc.

The profile we developed covers the entire RPW8 domain.

Last update:

October 2005 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RPW8, PS51153; RPW8 domain profile  (MATRIX)


1AuthorsXiao S. Ellwood S. Calis O. Patrick E. Li T. Coleman M. Turner J.G.
TitleBroad-spectrum mildew resistance in Arabidopsis thaliana mediated by RPW8.
SourceScience 291:118-120(2001).
PubMed ID11141561

2AuthorsXiao S. Emerson B. Ratanasut K. Patrick E. O'Neill C. Bancroft I. Turner J.G.
TitleOrigin and maintenance of a broad-spectrum disease resistance locus in Arabidopsis.
SourceMol. Biol. Evol. 21:1661-1672(2004).
PubMed ID15155802

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