PROSITE documentation PDOC51161ATP-cone domain profile
The ATP-cone domain is an ATP-binding module of ~85-90 residues, which is found in association with other domains such as class I+II and class III ribonucleotide reductases (see <PDOC00084>), the P-loop kinase or a zinc ribbon. It can be found as a single copy or in two-three tandem copies [1].
The ATP-cone is a compact, globular N-terminal domain which includes four α-helices and three β-strands (see <PDB:3R1R>). The structure of the ATP-cone domain resembles a cone with the surface formed by the four helices and the top by a three-stranded β-sheet. ATP is bound at the top of the cone just below the β-sheet [1].
Some proteins known to contain an ATP-cone domain are listed below:
- Ribonucleotide reductases (RNRs).
- Archaeal and deinococcal 2-phophoglycerate kinases (2-PGKs).
- Bacterial ybaD-like proteins.
The profile we developed covers the entire ATP-cone domain.
Last update:November 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Aravind L. Wolf Y.I. Koonin E.V. |
| Title | The ATP-cone: an evolutionarily mobile, ATP-binding regulatory domain. | |
| Source | J. Mol. Microbiol. Biotechnol. 2:191-194(2000). | |
| PubMed ID | 10939243 |
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