PROSITE documentation PDOC51207
PXA domain profile


The PX-associated (PXA) domain is a ~200-amino acid module of unknown function. Perhaps it is required for protein-protein interaction and/or filament formation. In addition to the phosphoinositide-binding PX (see <PDOC50195>) domain, the PXA domain can also be associated with a transmembrane domain and RGS (see <PDOC50132>), which binds to activated G-α subunits and is responsible for GTPase activating protein (GAP) function [1,2].

Some proteins known to contain a PXA domain are listed below:

  • Mammalian sorting nexins (SNXs) 13, 14 and 19.
  • Yeast structural protein MDM1.

The profile we developed covers the entire PXA domain.

Last update:

May 2006 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PXA, PS51207; PXA domain profile  (MATRIX)


1AuthorsZheng B. Ma Y.-C. Ostrom R.S. Lavoie C. Gill G.N. Insel P.A. Huang X.-Y. Farquhar M.G.
TitleRGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.
SourceScience 294:1939-1942(2001).
PubMed ID11729322

2AuthorsXu Y. Seet L.-F. Hanson B. Hong W.
TitleThe Phox homology (PX) domain, a new player in phosphoinositide signalling.
SourceBiochem. J. 360:513-530(2001).
PubMed ID11736640

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