PROSITE documentation PDOC51207PXA domain profile
The PX-associated (PXA) domain is a ~200-amino acid module of unknown function. Perhaps it is required for protein-protein interaction and/or filament formation. In addition to the phosphoinositide-binding PX (see <PDOC50195>) domain, the PXA domain can also be associated with a transmembrane domain and RGS (see <PDOC50132>), which binds to activated G-α subunits and is responsible for GTPase activating protein (GAP) function [1,2].
Some proteins known to contain a PXA domain are listed below:
- Mammalian sorting nexins (SNXs) 13, 14 and 19.
- Yeast structural protein MDM1.
The profile we developed covers the entire PXA domain.
Last update:May 2006 / First entry.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Zheng B. Ma Y.-C. Ostrom R.S. Lavoie C. Gill G.N. Insel P.A. Huang X.-Y. Farquhar M.G. |
| Title | RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. | |
| Source | Science 294:1939-1942(2001). | |
| PubMed ID | 11729322 | |
| DOI | 10.1126/science.1064757 |
| 2 | Authors | Xu Y. Seet L.-F. Hanson B. Hong W. |
| Title | The Phox homology (PX) domain, a new player in phosphoinositide signalling. | |
| Source | Biochem. J. 360:513-530(2001). | |
| PubMed ID | 11736640 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)