PROSITE documentation PDOC51215AWS domain profile
The SET domain is an evolutionarily conserved domain found predominantly in histone methyltransferases (HMTs) (see <PDOC50280>). Not all SET domain-containing proteins possess HMTase activities. The HTMase activity is probably restricted to a subset of SET domain proteins as it requires the combination of the SET domain with the adjacent cysteine-rich regions, one located N-terminally (pre-SET) and the other posterior to the SET domain (post-SET). In a subset of SET and post-SET containing proteins, a so-called associated with SET (AWS) domain is found instead of the pre-SET domain. In addition to the SET and post-SET domains to which it is always associated, the AWS domain can also be found with PWWP (see <PDOC50812>), AT-hook, WW (see <PDOC50020>), PHD (see <PDOC50016>) or BAH (see <PDOC51038>) [1,2,3].
Some proteins known to contain an AWS domain are listed below:
- Yeast set-2 protein.
- Human huntingtin-interacting protein B (HYPB).
The profile we developed covers the entire AWS domain.
Last update:June 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Doerks T. Copley R.R. Schultz J. Ponting C.P. Bork P. |
| Title | Systematic identification of novel protein domain families associated with nuclear functions. | |
| Source | Genome Res. 12:47-56(2002). | |
| PubMed ID | 11779830 | |
| DOI | 10.1101/ |
| 2 | Authors | Adhvaryu K.K. Morris S.A. Strahl B.D. Selker E.U. |
| Title | Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa. | |
| Source | Eukaryot. Cell 4:1455-1464(2005). | |
| PubMed ID | 16087750 | |
| DOI | 10.1128/EC.4.8.1455-1464.2005 |
| 3 | Authors | Sun X.-J. Wei J. Wu X.-Y. Hu M. Wang L. Wang H.-H. Zhang Q.-H. Chen S.-J. Huang Q.-H. Chen Z. |
| Title | Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. | |
| Source | J. Biol. Chem. 280:35261-35271(2005). | |
| PubMed ID | 16118227 | |
| DOI | 10.1074/jbc.M504012200 |
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