PROSITE documentation PDOC51220
NIDO domain profile


The ~180-residue NIDO domain is an extracellular domain of unknown function, found in nidogen (entactin) and hypothetical proteins. The NIDO domain is found in association with other domains, such as nidogen G2 β-barrel (see <PDOC50993>), thyroglobulin type-1 (see <PDOC00377>), LDLRB (see <PDOC51120>), AMOP (see <PDOC50856>), EGF-like (see <PDOC00021>), VWFD, IPT/TIG, or sushi/CCP/SCR (see <PDOC50923>) [1,2,3,4].

Some proteins known to contain a NIDO domain are listed below:

  • Vertebrate nidogen-1 (NID-1) or entactin, a sulfated glycoprotein widely distributed in basement membranes.
  • Vertebrate nidogen-2 (NID-2) or osteonidogen, a cell adhesion glycoprotein which is widely distributed in basement membranes.
  • Vertebrate α-tectorin.
  • Mammalian mucin-4 (MUC4), a highly glycosylated membrane-bound protein.
  • Xenopus ID14, a putative matrix protein.

The profile we developed covers the entire NIDO domain.

Last update:

June 2006 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NIDO, PS51220; NIDO domain profile  (MATRIX)


1AuthorsCiccarelli F.D. Doerks T. Bork P.
TitleAMOP, a protein module alternatively spliced in cancer cells.
SourceTrends Biochem. Sci. 27:113-115(2002).
PubMed ID11893501

2AuthorsDesseyn J.-L. Clavereau I. Laine A.
TitleCloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4.
SourceEur. J. Biochem. 269:3150-3159(2002).
PubMed ID12084055

3AuthorsBuchholz D.R. Ishizuya-Oka A. Shi Y.-B.
TitleSpatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis.
SourceGene Expr. Patterns 4:321-328(2004).
PubMed ID15053982

4AuthorsDuraisamy S. Ramasamy S. Kharbanda S. Kufe D.
TitleDistinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16.
SourceGene 373:28-34(2006).
PubMed ID16500040

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