PROSITE documentation PDOC51229
DCUN1 domain profile


The DCUN1 domain is an ~190-residue module found in the eukaryotic defective in cullin neddylation (DCN) protein family, which includes:

  • Yeast DCN1.
  • Vertebrate DCN1-like protein 1.
  • Vertebrate DCN1-like protein 2.
  • Vertebrate DCN1-like protein 4.

Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [1]. Although the DCUN1 domain function is unknown, it has been suggested that it has features of a basic helix-loop-helix leucine zipper (bHLH-ZIP) domain [2].

The DCUN1 domain can be found in association with an UBA-like domain [1].

The profile we developed covers the entire DCUN1 domain.

Last update:

July 2006 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

DCUN1, PS51229; DCUN1 domain profile  (MATRIX)


1AuthorsKurz T. Oezlu N. Rudolf F. O'Rourke S.M. Luke B. Hofmann K. Hyman A.A. Bowerman B. Peter M.
TitleThe conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
SourceNature 435:1257-1261(2005).
PubMed ID15988528

2AuthorsPourcel C. Jaubert J. Hadchouel M. Wu X. Schweizer J.
TitleA new family of genes and pseudogenes potentially expressing testis- and brain-specific leucine zipper proteins in man and mouse.
SourceGene 249:105-113(2000).
PubMed ID10831844

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