PROSITE documentation PDOC51229DCUN1 domain profile
The DCUN1 domain is an ~190-residue module found in the eukaryotic defective in cullin neddylation (DCN) protein family, which includes:
- Yeast DCN1.
- Vertebrate DCN1-like protein 1.
- Vertebrate DCN1-like protein 2.
- Vertebrate DCN1-like protein 4.
Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [1]. Although the DCUN1 domain function is unknown, it has been suggested that it has features of a basic helix-loop-helix leucine zipper (bHLH-ZIP) domain [2].
The DCUN1 domain can be found in association with an UBA-like domain [1].
The profile we developed covers the entire DCUN1 domain.
Last update:July 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kurz T. Oezlu N. Rudolf F. O'Rourke S.M. Luke B. Hofmann K. Hyman A.A. Bowerman B. Peter M. |
| Title | The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. | |
| Source | Nature 435:1257-1261(2005). | |
| PubMed ID | 15988528 | |
| DOI | 10.1038/nature03662 |
| 2 | Authors | Pourcel C. Jaubert J. Hadchouel M. Wu X. Schweizer J. |
| Title | A new family of genes and pseudogenes potentially expressing testis- and brain-specific leucine zipper proteins in man and mouse. | |
| Source | Gene 249:105-113(2000). | |
| PubMed ID | 10831844 |
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