PROSITE documentation PDOC51269
COMM domain profile


COMM (copper metabolism gene MURR1) domain proteins constitute a family initially identified as interacting partners of COMMD1 (previously known as MURR1), the prototype member of this protein family. COMMD1 is a multifunctional protein that has been shown to participate in two apparently distinct activities, regulation of the transcription factor NF-kappa-B and control of copper metabolism. The family is defined by the presence of a C-terminal motif termed COMM domain, which functions as an interface for protein-protein interactions. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms [1,2].

The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a β-sheet [1].

The profile we developed covers the entire COMM domain.

Last update:

November 2006 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

COMM, PS51269; COMM domain profile  (MATRIX)


1AuthorsBurstein E. Hoberg J.E. Wilkinson A.S. Rumble J.M. Csomos R.A. Komarck C.M. Maine G.N. Wilkinson J.C. Mayo M.W. Duckett C.S.
TitleCOMMD proteins, a novel family of structural and functional homologs of MURR1.
SourceJ. Biol. Chem. 280:22222-22232(2005).
PubMed ID15799966

2Authorsde Bie P. van de Sluis B. Burstein E. Duran K.J. Berger R. Duckett C.S. Wijmenga C. Klomp L.W.J.
TitleCharacterization of COMMD protein-protein interactions in NF-kappaB signalling.
SourceBiochem. J. 398:63-71(2006).
PubMed ID16573520

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